The role of timely measurement of galectin-3, NT-proBNP, cystatin C and hsTnT in predicting prognosis and heart function after heart transplantation

Clinical Chemistry and Laboratory Medicine : CCLM
Janka FranekováAntonín Jabor

Abstract

Changes of biomarkers measured soon after heart transplantation (HTx) can reflect different processes: cardiomyocyte necrosis (troponins, high-sensitivity cardiac TnT and TnI), heart function (natriuretic peptides, BNP and NT-proBNP), fibrosis (galectin-3 and ST2), and global cardiorenal risk (cystatin C). We assessed the prognostic role of hsTnT, NT-proBNP, galectin-3 and cystatin C during the early post-transplant period. A total of 121 consecutive post-HTx patients were assessed. The main outcomes were survival, left ventricular ejection fraction (LVEF) and rejection periods. Survival was assessed after intermediate (12 months) and long periods (total follow-up during study, median of survival 763 days, IR 527-1038 days). LVEF was assessed 12 months after HTx. Rejection was evaluated during follow-up. We report biomarker concentrations measured 10 days and 12 months after HTx. Ten days after HTx, cystatin C and hsTnT predicted death both under univariable and multivariable analysis. These two biomarkers along with galectin-3 were increased in patients with decreased LVEF measured 1 year after HTx. NT-proBNP did not show early prognostic power. None of the measured biomarkers predicted rejection, but hsTnT and NT-proBNP were ...Continue Reading

References

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Jul 12, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Janka FranekováAntonín Jabor

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Citations

Nov 5, 2016·JACC. Heart Failure·Alan MaiselWilliam Stendardi
Apr 26, 2018·BioMed Research International·Shihui FuLeiming Luo
Dec 10, 2019·Clinical Transplantation·Aws AlmuflehSharon Chih
Dec 6, 2017·International Journal of Molecular Medicine·Rui DongHui Yuan
Oct 17, 2020·Indian Journal of Thoracic and Cardiovascular Surgery : Official Organ, Association of Thoracic and Cardiovascular Surgeons of India·Jignesh K Patel

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Methods Mentioned

BETA
biopsy

Software Mentioned

plus
rms
package
R
JMP

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