PMID: 2509527Nov 1, 1989Paper

The role of topical agents in the healing of full-thickness wounds

The Journal of Dermatologic Surgery and Oncology
M A Watcher, R G Wheeland

Abstract

Eight topical agents in current use were studied for their effects on wound contraction and rate of reepithelialization of full-thickness excisions using a porcine animal model. The following agents were applied daily for a period of 27 days: scarlet red ointment, benzoyl peroxide lotion, bacitracin ointment, silver sulfadiazine cream, aloe vera gel, tretinoin cream, capsaicin cream, and mupirocin ointment. The rate of reepithelialization was significantly enhanced by treatment with capsaicin, bacitracin, silver sulfadiazine, and scarlet red, and was markedly retarded by treatment with tretinoin. Wound contraction was significantly retarded by mupirocin, bacitracin, and silver sulfadizine. Knowledge of the effects of topical agents on various aspects of healing allows the clinician to choose the most appropriate material to use in a given clinical situation to optimize the healing process and produce the best final result.

References

Aug 18, 1978·Brain Research·T M JessellA C Cuello
Nov 1, 1979·Archives of Dermatology·R G GeronemusW H Eaglstein
Jan 1, 1978·The Journal of Dermatologic Surgery and Oncology·W S Lynch, P L Bailin
Sep 1, 1978·The Journal of Dermatologic Surgery and Oncology·G J Colman, H H Roenigk
Oct 1, 1986·Journal of the American Academy of Dermatology·R Eichner
Mar 1, 1988·The Journal of Investigative Dermatology·T TanakaS Imamura
Jan 1, 1989·Archives of Dermatology·V C HungP A Hebda
Oct 1, 1986·Journal of the American Academy of Dermatology·S H Mandy
Sep 1, 1987·The Journal of Burn Care & Rehabilitation·J K PrasadP D Thomson
Mar 1, 1988·Plastic and Reconstructive Surgery·M Rodríguez-BigasA Suárez
Jul 1, 1987·Journal of the American Academy of Dermatology·J E BernsteinJ Y Roshal
Jan 1, 1973·International Journal of Dermatology·M E ZawahryM Helal
Apr 1, 1974·Archives of Surgery·J R Lloyd
Mar 1, 1968·Annals of Surgery·H P Ehrlich, T K Hunt
Jul 1, 1984·Clinics in Dermatology·S V Pollack
May 1, 1981·The Journal of Investigative Dermatology·J E BernsteinA L Lorincz
Jul 1, 1984·Clinics in Dermatology·W H EaglsteinO M Alvarez

❮ Previous
Next ❯

Citations

Mar 15, 2005·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·D Thaçi, H Schöfer
Mar 1, 1995·Physiology & Behavior·T Karrer, L Bartoshuk
Aug 1, 1990·Trends in Pharmacological Sciences·S Bevan, J Szolcsányi
Feb 1, 1995·Journal of the American Academy of Dermatology·A F Haas, R C Grekin
Jul 15, 1995·International Journal of Radiation Oncology, Biology, Physics·D B Roberts, E L Travis
Apr 1, 1995·Journal of Pain and Symptom Management·A BergerL Bartoshuk
Apr 7, 2000·Burns : Journal of the International Society for Burn Injuries·A J SingerS A McClain
Jan 7, 2000·Journal of Ethnopharmacology·T Reynolds, A C Dweck
Feb 9, 1999·The Journal of Emergency Medicine·P M Williford
Jun 10, 2000·International Journal of Dermatology·S R KarukondaL E Millikan
Apr 23, 2003·The Journal of Trauma·Charles P ChaleksonJesse Jaynes
Aug 1, 1993·The Journal of Dermatologic Surgery and Oncology·C D Brown, J A Zitelli
Apr 6, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Stephen R Tan, Whitney D Tope
Oct 13, 2006·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Mark Abdelmalek, James Spencer
Aug 5, 1999·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·A J SingerS A McClain
Jul 27, 2005·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Michael J Messingham, Christopher J Arpey
Sep 1, 1994·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·H P Hörmann, H C Korting
Jun 18, 2011·The Medical Clinics of North America·Peter A Lio, Elaine T Kaye
Nov 17, 2009·Infectious Disease Clinics of North America·Peter A Lio, Elaine T Kaye
May 12, 2001·The Journal of Investigative Dermatology·E BraungartK Degitz
Feb 15, 2008·The American Journal of Emergency Medicine·Bulent ErdurMelek Guryay
Mar 14, 2007·Seminars in Cutaneous Medicine and Surgery·Eva A HurstIsaac M Neuhaus
Mar 28, 2013·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Sharon Grundfest-Broniatowski
Oct 27, 2011·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Helmut SchöferUNKNOWN Paul Ehrlich Society for Chemotherapy (PEG)
Aug 17, 2004·Infectious Disease Clinics of North America·Peter A Lio, Elaine T Kaye
Feb 3, 2016·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Danielle de Campos PesetoDenise Gonçalves Priolli
Oct 1, 1991·International Journal of Dermatology·R M Shelton
Feb 14, 1998·Dermatologic Clinics·C Y Cho, J S Lo
May 13, 2006·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Mary D Boudreau, Frederick A Beland
Feb 26, 2000·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·A J SingerS A McClain
May 15, 2001·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·T P SullivanP Mertz
Aug 24, 2005·International Journal of Palliative Nursing·Clare Marlow, Jeremy Johnson
Jun 1, 2007·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·E TschachlerUNKNOWN German Society of Dermatology
Sep 11, 2003·Journal of Wound Care·M S AgrenJ Rygaard
Dec 6, 2008·The Journal of Dermatological Treatment·Dimosthenis TsoutsosKonstantinos Tamparopoulos
Jun 1, 2012·The Journal of Dermatological Treatment·Serap Gunes BilgiliAhmet Metin
Dec 17, 2010·Expert Review of Neurotherapeutics·Mark Wallace, Marco Pappagallo
Oct 11, 2019·PloS One·Luciana Schulthais AltoéReggiani Vilela Gonçalves
Jun 1, 2000·Infectious Disease Clinics of North America·E T Kaye
Apr 24, 2007·Journal of Medicinal Chemistry·Paul V FishRobert Webster

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.