The role of topical glucocorticoids in the treatment of rhinosinusitis

Vestnik otorinolaringologii
E G Shakhova

Abstract

The guidelines of the European position paper on rhinosinusitis and nasal polyps (EPOS, 2012) ascribe the highest strength and the most comprehensive evidence-based significance to the application of intranasal glucocorticosteroids (inGCS) as the first-line therapy for the patients presenting with acute and polypous rhinosinusitis; moreover they are recommended as the medications of choice for the treatment of chronic rhinosinusitis in the absence of polyps. The author presents the data concerning the mechanism of action, clinical effectiveness, and safety of inGCS used for the treatment of acute, recurrent, and chronic rhinosinusitis. It is shown that mometason furoate produces the favourable therapeutic effect and is possessed of beneficial pharmacodynamic and pharmacokinetic properties in the cases of its topical application. The comparative randomized clinical study (RCS) of the new preparation of mometason furoate in the form of the intranasal spray (manufactured by 'Teva' Ltd.) registered in the Russian Federation in 2015 has demonstrated that it can be considered as a therapeutic equivalent to nasonex.

References

May 4, 2005·The Journal of Allergy and Clinical Immunology·Albertien A C AukemaWytske J Fokkens
Dec 13, 2005·The Journal of Allergy and Clinical Immunology·Eli O MeltzerHeribert Staudinger
Jun 15, 2007·Infectious Disease Clinics of North America·Itzhak Brook
Aug 13, 2008·Primary Care Respiratory Journal : Journal of the General Practice Airways Group·Dermot Ryan
Mar 5, 2010·The Journal of Allergy and Clinical Immunology·Mark S Dykewicz, Daniel L Hamilos
Mar 6, 2010·Expert Opinion on Pharmacotherapy·Itzhak Brook
Jul 16, 2010·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Alicja GrzankaJerzy Jarząb
Aug 2, 2011·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Jonathan A BernsteinLinda S Levin
Mar 23, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anthony W Chow Infectious Diseases Society of America

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
Hua-bin LiGeng Xu
Rhinology. Supplement
European Academy of Allergology and Clinical Immunology
Vestnik otorinolaringologii
E P KarpovaD A Tulupov
© 2022 Meta ULC. All rights reserved