The Role of Transient Receptor Potential Vanilloid 4 in Pulmonary Inflammatory Diseases

Frontiers in Immunology
Rachel G ScheragaMitchell A Olman

Abstract

Ion channels/pumps are essential regulators of organ homeostasis and disease. In the present review, we discuss the role of the mechanosensitive cation channel, transient receptor potential vanilloid 4 (TRPV4), in cytokine secretion and pulmonary inflammatory diseases such as asthma, cystic fibrosis (CF), and acute lung injury/acute respiratory distress syndrome (ARDS). TRPV4 has been shown to play a role in lung diseases associated with lung parenchymal stretch or stiffness. TRPV4 indirectly mediates hypotonicity-induced smooth muscle contraction and airway remodeling in asthma. Further, the literature suggests that in CF TRPV4 may improve ciliary beat frequency enhancing mucociliary clearance, while at the same time increasing pro-inflammatory cytokine secretion/lung tissue injury. Currently it is understood that the role of TRPV4 in immune cell function and associated lung tissue injury/ARDS may depend on the injury stimulus. Uncovering the downstream mechanisms of TRPV4 action in pulmonary inflammatory diseases is likely important to understanding disease pathogenesis and may lead to novel therapeutics.

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Citations

Oct 4, 2019·Human & Experimental Toxicology·C D Lindsay, C M Timperley
Oct 18, 2019·American Journal of Respiratory Cell and Molecular Biology·Rachel G Scheraga, Mitchell A Olman
Jun 3, 2020·International Journal of Molecular Sciences·Tamara RosenbaumFrancisco Torres-Quiroz
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Sep 7, 2020·Annals of the New York Academy of Sciences·Satyanarayana Achanta, Sven-Eric Jordt
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Jan 24, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rachel G ScheragaMitchell A Olman
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May 14, 2021·Frontiers in Molecular Biosciences·Liangliang LiuTingting Zhou
Sep 17, 2021·Nature Reviews. Drug Discovery·Ari-Pekka KoivistoArpad Szallasi

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