PMID: 7542823Aug 1, 1995Paper

The role of transrectal ultrasound-guided biopsy-based staging, preoperative serum prostate-specific antigen, and biopsy Gleason score in prediction of final pathologic diagnosis in prostate cancer

Urology
P NarayanJ T Spaulding

Abstract

To evaluate the role of ultra sound-guided systematic and lesion-directed biopsies, biopsy gleason score, preoperative serum prostate-specific antigen (PSA) as three objective and reproducible variables to provide a reliable combination in preoperative identification of risk of extraprostatic extension in patients with clinically localized prostate cancer. The case records of 813 patients who underwent radical prostatectomy for clinically localized prostate cancer were analyzed. All had multiple systematic biopsies, two to three from each lobe, in addition to lesion-directed biopsies. Additionally, biopsies were done on seminal vesicles (SVs), if abnormal. Based on biopsy results, patients were classified as having stage B1 (T2a-T2b) or B2 (T2c) disease, depending on whether biopsies from one or both lobes were positive and stage C (T3) if there was evidence of SV involvement by biopsy of biopsies from areas of extracapsular extension as seen on transrectal ultrasound (TRUS) were positive. Logistic regression analyses with log likelihood chi-square test was used to define the correlation between individual as well as combination of preoperative variables and pathologic stage. On final pathologic examination, 473 (58%) patients ...Continue Reading

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Citations

Apr 27, 2007·Current Urology Reports·Gregory L LacyJavier Hernandez
Jun 1, 1996·Urology·A E KatzR Buttyan
Feb 11, 1998·Urology·J V Jepsen, R C Bruskewitz
Jul 17, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Laurent SalomonJean-Leon Lagrange
Apr 15, 2008·Trends in Endocrinology and Metabolism : TEM·E P Diamandis
Jul 15, 2003·Urologic Oncology·Javid Javidan, David P Wood
Jun 8, 2001·International Journal of Urology : Official Journal of the Japanese Urological Association·S EgawaS Baba
Nov 9, 2000·BJU International·W D DunsmuirR S Kirby
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Apr 24, 2008·AJR. American Journal of Roentgenology·Emanuele CascianiGian Franco Gualdi
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Oct 1, 2008·Cancer·Shahrokh F ShariatMichael W Kattan
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Jan 22, 2005·European Urology·Saadettin Yilmaz EskicorapciHaluk Ozen

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