The Role of Transthyretin in Oligodendrocyte Development.

Scientific Reports
B AlshehriSamantha J Richardson

Abstract

Transthyretin (TTR) is a protein that binds and distributes thyroid hormones (THs) in blood and cerebrospinal fluid. Previously, two reports identified TTR null mice as hypothyroid in the central nervous system (CNS). This prompted our investigations into developmentally regulated TH-dependent processes in brains of wildtype and TTR null mice. Despite logical expectations of a hypomyelinating phenotype in the CNS of TTR null mice, we observed a hypermyelination phenotype, synchronous with an increase in the density of oligodendrocytes in the corpus callosum and anterior commissure of TTR null mice during postnatal development. Furthermore, absence of TTR enhanced proliferation and migration of OPCs with decreased apoptosis. Neural stem cells (NSCs) isolated from the subventricular zone of TTR null mice at P21 revealed that the absence of TTR promoted NSC differentiation toward a glial lineage. Importantly, we identified TTR synthesis in OPCs, suggestive of an alternate biological function in these cells that may extend beyond an extracellular TH-distributor protein. The hypermyelination mechanism may involve increased pAKT (involved in oligodendrocyte maturation) in TTR null mice. Elucidating the regulatory role of TTR in NSC a...Continue Reading

References

Oct 1, 1976·Experimental Neurology·S G Waxman, H A Swadlow
Jul 1, 1986·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A J StauderP Hudson
Jun 1, 1986·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·G MorstynP Bhathal
Mar 29, 1985·Biochemical and Biophysical Research Communications·P W DicksonG Schreiber
Jun 1, 1980·The Journal of Cell Biology·K D McCarthy, J de Vellis
Oct 20, 1994·Behavioural Brain Research·P BerbelJ Ramón Cerezo
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·V EpiskopouE J Robertson
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C Lois, A Alvarez-Buylla
Feb 1, 1997·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·G Schreiber, S J Richardson
Jan 1, 1997·Molecular and Cellular Neurosciences·S C AhlgrenM C Raff
Mar 10, 1999·Methods : a Companion to Methods in Enzymology·R C Armstrong
Jun 7, 2000·Methods in Molecular Biology·E E FrostC Ffrench-Constant
Jul 6, 2004·Neuroscience Letters·Michael J HaasArshag D Mooradian
Feb 25, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G F LemkineB A Demeneix
Dec 24, 2005·Nature Reviews. Neuroscience·William D RichardsonNigel Pringle
Jul 28, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bénédicte MennArturo Alvarez-Buylla
Jun 5, 2007·Nature Protocols·Ying ChenQ Richard Lu
Apr 15, 2008·Neuroscience Letters·Tatsufumi MurakamiYoshihide Sunada
Jun 17, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·András VinczeHajnalka Abrahám
Jul 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ana I FloresWendy B Macklin
Oct 7, 2008·Experimental Neurology·Mónica Mendes Sousa, Maria João Saraiva
May 29, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·S Priyadarshini NarayananWendy B Macklin
Jun 16, 2010·Brain Research·Tatsufumi MurakamiYoshihide Sunada
Jan 18, 2011·Brain Research Reviews·Oscar Gonzalez-Perez, Arturo Alvarez-Buylla
Oct 25, 2012·American Journal of Physiology. Endocrinology and Metabolism·Julie A MonkSamantha J Richardson
Oct 17, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yao Lulu XingTobias D Merson
Nov 28, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Akihiro IshiiRashmi Bansal
May 23, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kelly MichelSharyl L Fyffe-Maricich
Apr 22, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Enric Domènech-EstévezJames L Salzer
Jun 17, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Akihiro IshiiRashmi Bansal

❮ Previous
Next ❯

Citations

Sep 29, 2020·Frontiers in Neuroscience·Pieter VancampSylvie Remaud
Jan 26, 2021·Frontiers in Neuroendocrinology·Maurice PagninMary Tolcos
Jul 24, 2021·Cellular and Molecular Life Sciences : CMLS·Joana MagalhãesMárcia Almeida Liz
Aug 22, 2021·Ecotoxicology and Environmental Safety·Leslie SchwendimannPierre Gressens
Oct 12, 2021·Neuroscience Letters·Maurice PagninSamantha J Richardson

❮ Previous
Next ❯

Methods Mentioned

BETA
laser
flow cytometry
confocal microscopy
FACS
electron microscopy
PCR
electrophoresis
protein assay
X-ray
immunoprecipitation

Software Mentioned

GraphPad Prism
FlowJo
SPSS
Cellsens dimension

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

Journal of Neurochemistry
Carolina Estima FlemingMónica Mendes Sousa
American Journal of Physiology. Endocrinology and Metabolism
Julie A MonkSamantha J Richardson
© 2021 Meta ULC. All rights reserved