The role of TREM2 in Alzheimer's disease and other neurodegenerative disorders

Lancet Neurology
Susana CarmonaRita Guerreiro


Alzheimer's disease is a genetically complex disorder; rare variants in the triggering receptor expressed on myeloid cells 2 (TREM2) gene have been shown to as much as triple an individual's risk of developing Alzheimer's disease. TREM2 is a transmembrane receptor expressed in cells of the myeloid lineage, and its association with Alzheimer's disease supports the involvement of immune and inflammatory pathways in the cause of the disease, rather than as a consequence of the disease. TREM2 variants associated with Alzheimer's disease induce partial loss of function of the TREM2 protein and alter the behaviour of microglial cells, including their response to amyloid plaques. TREM2 variants have also been shown to cause polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy and frontotemporal dementia. Although the low frequency of TREM2 variants makes it difficult to establish robust genotype-phenotype correlations, such studies are essential to enable a comprehensive understanding of the role of TREM2 in different neurological diseases, with the ultimate goal of developing novel therapeutic approaches.


Nov 14, 2018·Neuropathology and Applied Neurobiology·Henrik ZetterbergJ D Rohrer
Dec 23, 2018·Neuropathology and Applied Neurobiology·B BorroniE Buratti
Feb 2, 2019·Continuum : Lifelong Learning in Neurology·Gil D Rabinovici
Mar 22, 2019·Protein Science : a Publication of the Protein Society·Manuel A CastroCharles R Sanders
Mar 15, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Edwin JabbariHuw R Morris
Sep 19, 2019·Brain : a Journal of Neurology·Francesco PanzaBruno P Imbimbo
Aug 28, 2019·Journal of Alzheimer's Disease : JAD·Michela GuglielmottoElena Tamagno
Aug 14, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Pierre-François MeyerAlzheimer's Disease Neuroimaging Initiative
Feb 2, 2020·Molecular Neurodegeneration·Tosha WilliamsParamita Chakrabarty
Feb 22, 2020·Scientific Reports·Zachery MoorePeter J Crack
Dec 4, 2019·Topics in Magnetic Resonance Imaging : TMRI·Luke W BonhamJennifer S Yokoyama
Aug 28, 2019·Scientific Reports·Sarah JollyErnest Palomer
Jul 17, 2020·Seminars in Neurology·Jonathan D CherryLee E Goldstein
Aug 16, 2019·Science Translational Medicine·Yuetiva DemingCarlos Cruchaga
Oct 28, 2019·Frontiers in Cellular Neuroscience·Hailan YaoDaniel Paris
Oct 2, 2019·Neural Regeneration Research·Bettina M Foidl, Christian Humpel
Dec 20, 2018·Frontiers in Neurology·Adonis SferaCarolina Osorio
Oct 18, 2019·Expert Opinion on Drug Discovery·Miroslava Cuperlovic-Culf, Amanpreet Badhwar
Nov 7, 2019·Current Genetic Medicine Reports·Daniel W SirkisJennifer S Yokoyama
Apr 3, 2020·International Journal of Molecular Sciences·Chen-Ling GanTae Ho Lee
Jun 15, 2019·Cellular and Molecular Life Sciences : CMLS·Santiago RiveraKévin Baranger
Jan 8, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michal SchwartzHila Ben-Yehuda
Apr 19, 2020·Expert Review of Neurotherapeutics·Eleazar Ramírez HernándezI Daniel Limón Pérez de León
Dec 10, 2019·Cerebral Cortex·Nathalie Bodd HalaasAnders M Fjell
Jan 8, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mitsuru ShinoharaNaoyuki Sato
Feb 24, 2020·Journal of Molecular Neuroscience : MN·Vasileios SiokasEfthimios Dardiotis
Jul 1, 2020·Nature Reviews. Neuroscience·Sara Saez-Atienzar, Eliezer Masliah
Sep 26, 2020·Frontiers in Aging Neuroscience·Ishan Agrawal, Sushmita Jha
Sep 10, 2020·Journal of Personalized Medicine·Chiara ArgentatiSabata Martino
Sep 26, 2020·Frontiers in Molecular Neuroscience·Emily J Koller, Paramita Chakrabarty
May 28, 2019·Scientific Reports·Estrella Morenas-RodríguezAlberto Lleó
Apr 23, 2020·Journal of Clinical Neurology·Min Jin JiYoung Noh
Jul 8, 2020·International Journal of Molecular Sciences·Sujin KimWeon Kuu Chung
Nov 27, 2020·Translational Neurodegeneration·Hyuk Sung Kwon, Seong-Ho Koh
Dec 10, 2020·Translational Psychiatry·Si-Han ChenYan-Jiang Wang
Jan 27, 2021·Annual Review of Pathology·Caitlin S LatimerThomas J Montine
Feb 5, 2021·Frontiers in Cellular Neuroscience·Joe SteinmanZhong-Ping Feng
Dec 15, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Trine Holt EdwinAnne-Brita Knapskog
Mar 6, 2021·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Julie HoogmartensChristine Van Broeckhoven
Mar 9, 2021·Frontiers in Immunology·Laura N VerboonAndrew D Greenhalgh
May 23, 2020·Neurobiology of Disease·Rita GuerreiroJose Bras
Apr 16, 2021·Genome Medicine·Federica PerroneChristine Van Broeckhoven
Mar 31, 2021·The European Journal of Neuroscience·Sadat ShafiFaheem Hyder Pottoo

Related Concepts

Related Feeds

Alzheimer's Disease: Genetics

Alzheimer's disease is a neurodegenerative disease. Discover genetic and epigenetic aspects of Alzheimer’s disease, including genetic markers and genomic structural variations with this feed.

Alzheimer's Disease: Microglia

Microglia are a type of glial cell found throughout the brain and spinal cord. Microglia have been found to be associated with Alzheimer's disease development and progression. Here are the latest discoveries pertaining to Alzheimer's disease and microglia.