The role of TRPC6 in seizure susceptibility and seizure-related neuronal damage in the rat dentate gyrus

Neuroscience
Y-J Kim, T-C Kang

Abstract

Transient receptor potential canonical channel-6 (TRPC6) forms Ca(2+)-permeable non-selective cation channels in neurons. Although TRPC6 plays an important role in neurite outgrowth and neuronal survival during development, TRPC6 expression profiles available to identify distinctive hippocampal neuronal damage and hippocampal excitability in epilepsy are less defined. As compared to normal animals, TRPC6 expression was down-regulated in chronic epileptic rats showing spontaneous recurrent seizures. TRPC6 knockdown increased seizure susceptibility, excitability ratio and paired-pulse inhibition in the dentate gyrus (DG) of normal animals. Furthermore, TRPC6 knockdown promoted programmed neuronal necrosis in dentate granule cells, but prevented it in CA1 and CA3 neurons following status epilepticus. The present data suggest for the first time that TRPC6 may inhibit seizure susceptibility and neuronal vulnerability in the rat DG.

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Citations

Feb 16, 2017·Scientific Reports·Ji Yang KimJi-Eun Kim
Jan 26, 2021·Frontiers in Cell and Developmental Biology·Jaepyo JeonMichael X Zhu
Oct 30, 2020·Frontiers in Neuroscience·Simonetta SipioneVaibhavi Kadam
Feb 20, 2021·Frontiers in Cell and Developmental Biology·Lu LiuShengmei Zhu
Mar 23, 2021·Frontiers in Cell and Developmental Biology·Kihwan LeeChul-Kyu Park
Jun 21, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Pavan ThapakShyam S Sharma
Jul 31, 2021·Frontiers in Cell and Developmental Biology·Ruxin XieXiaotang Fan

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