The Role of TRPV4 in Regulating Innate Immune Cell Function in Lung Inflammation.

Frontiers in Immunology
Rachel G ScheragaMitchell A Olman

Abstract

Ion channels/pumps are essential regulators of innate immune cell function. Macrophages have been increasingly recognized to have phenotypic plasticity and location-specific functions in the lung. Transient receptor potential vanilloid 4 (TRPV4) function in lung injury has been shown to be stimulus- and cell-type specific. In the current review, we discuss the importance of TRPV4 in macrophages and its role in phagocytosis and cytokine secretion in acute lung injury/acute respiratory distress syndrome (ARDS). Furthermore, TRPV4 controls a MAPK molecular switch from predominately c-Jun N-terminal kinase, JNK activation, to that of p38 activation, that mediates phagocytosis and cytokine secretion in a matrix stiffness-dependent manner. Expanding knowledge regarding the downstream mechanisms by which TRPV4 acts to tailor macrophage function in pulmonary inflammatory diseases will allow for formulation of novel therapeutics.

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Citations

Mar 3, 2021·Current Opinion in Organ Transplantation·Nathan HaywoodVictor E Laubach
Apr 4, 2021·International Journal of Molecular Sciences·Joanna K BujakPiotr Bednarczyk
Jun 25, 2021·Chemico-biological Interactions·Sahar M Jaffal, Manal A Abbas
May 8, 2021·The Annals of Thoracic Surgery·Nathan HaywoodVictor E Laubach

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