The role of tumor suppressor gene SOX11 in prostate cancer

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Zhiyong YaoHeqing Guo

Abstract

SOX genes play an important role in a number of developmental processes. The transcription factor SOX11 is one of the members of the SOX family emerging as important transcriptional regulators. The aim of this study was to investigate the role of SOX11 in prostate cancer (PCa) and its expression pattern and clinical significance. The gene expression of SOX11 in human PCa tissues compared with benign prostate hyperplasia (BPH) tissues was detected using real-time quantitative reverse transcriptase-polymerase chain reaction (QRT-PCR) analysis and immunohositochemistry. SOX11 overexpression cell model was used to examine the role of SOX11 in cell growth and metastasis in vitro. The results showed that the positive rate of SOX11 staining was 16.67 % (10/60) in cases of prostatic carcinoma and 81.67 % (49/60) in cases of BPH, and the difference of SOX11 expression between PCa and BPH was statistically significant (P < 0.001). SOX11 mRNA level was lowly expressed in PCa cell lines compared to RWPE-1. SOX11 overexpression suppresses PCa cell migration and invasion. In conclusion, our findings demonstrate that SOX11 could suppress cell proliferation, migration, and invasion of PCa in vitro.

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Citations

Dec 5, 2015·Expert Review of Anticancer Therapy·Donald S ColbournOwen A O'Connor
Aug 1, 2016·Seminars in Cell & Developmental Biology·Ya-Ru Xu, Wan-Xi Yang
Sep 19, 2019·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Zhi LiuJian Shui Li
Jan 10, 2018·International Journal of Experimental Pathology·Apiwat PugongchaiPichet Sampatanukul
Jul 15, 2017·The Journal of Pathology·Erik OliemullerBeatrice A Howard
Jun 19, 2019·Therapeutic Advances in Medical Oncology·Zhi YangZhenxiao Jin
Apr 3, 2019·Biochimie·Tianjiao ShanYi-Wen Huang
Sep 25, 2020·Experimental and Molecular Pathology·Yoshifumi S HirokawaMasatoshi Watanabe

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