The role of two-component regulatory system in β-lactam antibiotics resistance

Microbiological Research
Li LingzhiZhou Xiaohui

Abstract

The irrational use of antibiotics in agriculture and in the medical field has led to a variety of pathogenic microorganisms that produce drug resistance and even multidrug resistance. B-lactam is one of the most widely used antibiotics to treat infectious diseases. Resistance to β-lactam resistance can be primarily due to the presence β-lactamase, mutation of β-lactam targets and overexpression of efflux pumps. Two-component regulatory systems are composed of histidine kinase and response regulator that regulate gene expression under different environmental conditions. In this review, we summarized the mechanisms by which β-lactam resistance is developed and the role of the two-component regulatory system in β-lactam resistance.

Citations

Feb 23, 2020·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Tanveer AhmedV Venkateswara Sarma
May 18, 2020·Environmental Monitoring and Assessment·Cansu Ilke KuruSinan Akgöl
Apr 13, 2019·International Journal of Molecular Sciences·Anjali Y BhagirathKangmin Duan
Jul 2, 2019·NeoReviews·Carina B Ramirez, Joseph B Cantey
Feb 2, 2020·International Journal of Medical Microbiology : IJMM·Neal ToewiwatSuvit Loprasert
Mar 20, 2021·The Journal of Antimicrobial Chemotherapy·Hsin-Hui HuangTsuey-Ching Yang
May 20, 2021·Environmental Research·Chaoyu TongJianye Zhang
Jul 3, 2021·Biochemical and Biophysical Research Communications·So Yeon Cho, Sung-Il Yoon

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