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The role of ubiquitin ligase E3A in polarized contact guidance and rescue strategies in UBE3A-deficient hippocampal neurons

Molecular Autism

Dec 5, 2019

Ilaria TonazziniMarco Cecchini

Abstract

Although neuronal extracellular sensing is emerging as crucial for brain wiring and therefore plasticity, little is known about these processes in neurodevelopmental disorders. Ubiquitin protein ligase E3A (UBE3A) plays a key role in neurodevelopment. Lack of UBE3A leads to Angelman syn...read more

Mentioned in this Paper

Advice
Actins
Axon Branching
Neurons
Brain
Ubiquitinated Proteins
Neurodevelopmental Disorders
Actin-Binding Protein
Neuron Guidance
Autistic Disorder
1
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The role of ubiquitin ligase E3A in polarized contact guidance and rescue strategies in UBE3A-deficient hippocampal neurons

Molecular Autism

Dec 5, 2019

Ilaria TonazziniMarco Cecchini

PMID: 31798818

DOI: 10.1186/s13229-019-0293-1

Abstract

Although neuronal extracellular sensing is emerging as crucial for brain wiring and therefore plasticity, little is known about these processes in neurodevelopmental disorders. Ubiquitin protein ligase E3A (UBE3A) plays a key role in neurodevelopment. Lack of UBE3A leads to Angelman syn...read more

Mentioned in this Paper

Advice
Actins
Axon Branching
Neurons
Brain
Ubiquitinated Proteins
Neurodevelopmental Disorders
Actin-Binding Protein
Neuron Guidance
Autistic Disorder
1

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The limbic system is comprised of several different parts of the brain involved in emotion, motivation, learning, and memory. Discover the latest research on the limbic system here.

Chromosomal Deletion

Chromosomal deletion includes the loss of a gene sequence of DNA. The location and the genes deleted determines the significance of this abnormality. There are many identified genetic disorders that are a result from chromosomal deletion including cri du chat and Prader-Willi syndrome. Discover the latest research on chromosomal deletions here.

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