The role of ultrasound in enhancing mesenchymal stromal cell-based therapies.

Stem Cells Translational Medicine
Daniel D LiuAvnesh S Thakor

Abstract

Mesenchymal stromal cells (MSCs) have been a popular platform for cell-based therapy in regenerative medicine due to their propensity to home to damaged tissue and act as a repository of regenerative molecules that can promote tissue repair and exert immunomodulatory effects. Accordingly, a great deal of research has gone into optimizing MSC homing and increasing their secretion of therapeutic molecules. A variety of methods have been used to these ends, but one emerging technique gaining significant interest is the use of ultrasound. Sound waves exert mechanical pressure on cells, activating mechano-transduction pathways and altering gene expression. Ultrasound has been applied both to cultured MSCs to modulate self-renewal and differentiation, and to tissues-of-interest to make them a more attractive target for MSC homing. Here, we review the various applications of ultrasound to MSC-based therapies, including low-intensity pulsed ultrasound, pulsed focused ultrasound, and extracorporeal shockwave therapy, as well as the use of adjunctive therapies such as microbubbles. At a molecular level, it seems that ultrasound transiently generates a local gradient of cytokines, growth factors, and adhesion molecules that facilitate MSC...Continue Reading

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Citations

Sep 23, 2020·Genes·Beatriz de LucasBeatriz G Gálvez
Oct 9, 2020·Cell Transplantation·Mehdi RazaviAvnesh S Thakor
Oct 18, 2020·Journal of Cellular and Molecular Medicine·Kee W JangJoseph A Frank
Feb 13, 2021·Expert Opinion on Biological Therapy·Michail E KlontzasApostolos H Karantanas
Apr 16, 2021·Advanced Science·Anna AndrzejewskaMiroslaw Janowski
Apr 30, 2020·Molecular Therapy. Methods & Clinical Development·Mujib UllahAvnesh S Thakor
Oct 12, 2021·Technology in Cancer Research & Treatment·Sai Priyanka Kodam, Mujib Ullah

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