The role of upper gastrointestinal endoscopy in the era of modern antiretroviral therapy

European Journal of Gastroenterology & Hepatology
Marcel NkuizeMichel Buset

Abstract

Gastrointestinal disorders are common in HIV-positive patients and, in some cases, may be related to antiretroviral therapy (ART), making it difficult to determine the need for upper gastrointestinal (UGI) endoscopy. The primary aim of this study was to determine whether lymphocyte T CD4 cell counts were correlated with indications for endoscopy in these patients and with endoscopic diagnosis. We prospectively collected data from consecutive HIV-positive patients undergoing UGI endoscopy between 2007 and 2013, and included 265 patients who had been receiving ART for at least 6 months. Parameters studied were demographics, immune parameters, comorbidities, comedications, indications for endoscopy, and endoscopic, pathologic, and microbiologic findings. The most frequent indications for UGI endoscopy were gastroesophageal reflux, epigastric pain, and other. Peptic esophagitis, esophageal candidiasis, and normal endoscopy were the most common diagnoses. The prevalence rates of Helicobacter pylori infection and neoplasia were 26.4 and 1.8%, respectively. Patients with CD4+ counts 200 cells/μl or more had significantly lower rates of macrolide and nonmacrolide use, fewer comorbidities, and were less likely to have AIDS than patients...Continue Reading

References

Oct 17, 1991·The New England Journal of Medicine·J ParsonnetR K Sibley
Feb 24, 2000·The American Journal of Gastroenterology·K E MönkemüllerC M Wilcox
Apr 16, 2002·European Journal of Gastroenterology & Hepatology·Edouard LouisMichel Deltenre
Feb 4, 2006·Nature Clinical Practice. Gastroenterology & Hepatology·Yuhong YuanRichard H Hunt
Dec 25, 2007·AIDS Patient Care and STDs·Frank RomanelliBrian S Murphy
Jul 11, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Helen KovariUNKNOWN Swiss HIV Cohort Study
Dec 25, 2013·PloS One·Hasina SamjiUNKNOWN North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of IeDEA
Apr 30, 2014·Helicobacter·Daniel T NevinRobert M Genta
May 20, 2014·Journal of Addictive Behaviors, Therapy & Rehabilitation·Patricia A Cioe
Jul 20, 2014·JAMA : the Journal of the American Medical Association·Huldrych F GünthardPaul A Volberding

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Citations

Feb 6, 2016·Current Treatment Options in Gastroenterology·Nitin K Ahuja, John O Clarke

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Methods Mentioned

BETA
biopsy
PCR
biopsies

Software Mentioned

SAS

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