The role of urinary soluble endoglin in the diagnosis of pre-eclampsia: comparison with soluble fms-like tyrosine kinase 1 to placental growth factor ratio

BJOG : an International Journal of Obstetrics and Gynaecology
Catalin S BuhimschiIrina A Buhimschi

Abstract

Endoglin, an anti-angiogenic glycoprotein expressed on endothelial cells, has been proposed recently as a biomarker of pre-eclampsia (PE). Given that PE is characterised by an imbalance of angiogenic factors, we sought to determine the clinical utility of urinary soluble endoglin, relative to the soluble fms-like tyrosine kinase 1 to placental growth factor (PlGF) ratio, in the diagnosis of PE during gestation. Prospective observational cohort. Tertiary referral university hospital. Two hundred and thirty-four pregnant women were enrolled prospectively in the following groups: healthy controls, n = 63; gestational age (GA), median (interquartile range), 33 weeks (27-39 weeks); chronic hypertension, n = 27; GA, 33 weeks (30-36 weeks); mild PE, n = 38; GA, 37 weeks (34-40 weeks); severe PE, n = 106; GA, 32 weeks (29-37 weeks). Free urinary levels of soluble endoglin, soluble fms-like tyrosine kinase 1 and PlGF were measured by sensitive and specific immunoassay. Levels for all urinary analytes were normalised to creatinine. Urinary soluble endoglin, and the soluble fms-like tyrosine kinase 1 to PlGF ratio. In healthy controls, urinary soluble endoglin levels were increased significantly at term relative to those earlier in gestat...Continue Reading

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May 11, 2011·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Nora Langballe RosselandAnnetine Staff
Aug 10, 2013·Advances in Chronic Kidney Disease·Srujana PolsaniBelinda Jim
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May 21, 2015·Clinical Chemistry and Laboratory Medicine : CCLM·Nathalie AcestorBernhard H Weigl

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