The Role of Vascular Calcification in Heart Failure and Cognitive Decline

Pulse
Hao-Min ChengChen-Huan Chen

Abstract

Vascular calcification is heterogeneous and triggered by multiple mechanisms. It has been implicated in the development of heart failure with preserved ejection fraction (HFpEF) and cognitive function impairment. Understanding the pathophysiology of vascular calcification may help us improve the management of HFpEF, atherosclerosis, accelerated arterial stiffness, hypertension, and cognitive dysfunction. Currently, there are no effective strategies for treating accelerated arterial stiffness. This may indicate that once arterial stiffness or vascular calcification has developed, it may be less likely to stop the ongoing pathophysiology. Therefore, earlier intervention targeting the probable pathways of vascular calcification may benefit the patients with vascular calcification and related pathological conditions. In this review, we briefly discuss the proposed pathophysiological roles of vascular calcification in the development of heart failure and cognitive decline, the animal models used to study the link between vascular calcification and cardiovascular diseases, and the possible corresponding management strategies.

References

Aug 1, 1989·Circulation Research·H AsanoiT Kameyama
Feb 1, 1995·Cardiovascular Drugs and Therapy·G G Belz
Feb 17, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·P A PriceM K Williamson
May 12, 2000·Journal of the American College of Cardiology·J S GottdienerR C Boineau
Sep 18, 2002·Kidney International·Ronald M A HenryCoen D A Stehouwer
Jan 23, 2003·Journal of the American Society of Nephrology : JASN·Moriz BuzelloKerstin Amann
Sep 30, 2003·Journal of the American Society of Nephrology : JASN·Susanne BroLars B Nielsen
Feb 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·H S Markus
Mar 23, 2004·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Mei Y Speer, Cecilia M Giachelli
May 7, 2004·The New England Journal of Medicine·Michael R ZileWilliam H Gaasch
Nov 1, 2005·Journal of the American College of Cardiology·Carmel M McEnieryUNKNOWN ACCT Investigators
Jul 21, 2006·The New England Journal of Medicine·Theophilus E OwanMargaret M Redfield
Nov 1, 2006·Advances in Cardiology·Rachel H MackeyKim Sutton-Tyrrell
Dec 19, 2006·European Journal of Heart Failure·Raymond L C VogelsHenry C Weinstein
Jul 4, 2007·Circulation·Ernesto L SchiffrinJohannes F E Mann
Nov 13, 2008·The New England Journal of Medicine·Barry M MassieUNKNOWN I-PRESERVE Investigators
Jan 9, 2009·Kidney International·Koba A LomashviliW Charles O'Neill
Jul 11, 2009·The American Journal of Pathology·Susann HelasLorenz C Hofbauer
Feb 24, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mohamed M NasrallahUsama A A Sharaf El Din
Mar 30, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Nigel D ToussaintPeter G Kerr
Aug 4, 2010·Circulation·Angela L JeffersonWarren J Manning
Nov 23, 2011·Circulation·James E Udelson
Mar 23, 2012·Kidney International·Pablo A Ureña Torres, Marc De Broe
May 16, 2012·Frontiers in Physiology·Paul D Chantler, Edward G Lakatta
Oct 3, 2012·Journal of the Neurological Sciences·Michael L AloscoJohn Gunstad
Jan 17, 2013·Stroke; a Journal of Cerebral Circulation·Adina Zeki Al HazzouriUNKNOWN Health ABC Study
Apr 5, 2013·Journal of Hypertension·Natacha Levi MarpillatPatrick Maison
Aug 22, 2013·Calcified Tissue International·Yang LeiNaren Vyavahare
Dec 29, 2013·American Journal of Physiology. Renal Physiology·A Peralta-RamírezE Aguilera-Tejero
Mar 22, 2014·Journal of the American Society of Nephrology : JASN·Akihiro ShimomuraHiromi Rakugi
May 20, 2014·Journal of Atherosclerosis and Thrombosis·Katsuya IijimaYasuyoshi Ouchi
Jun 20, 2014·World Journal of Cardiology·Thanh-Mai Vo, Sinee Disthabanchong
Mar 5, 2015·Circulation·Yigal AbramowitzRaj R Makkar

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Citations

May 20, 2020·ESC Heart Failure·Marian WesselingSaskia C A de Jager
Jun 18, 2020·International Journal of Nanomedicine·Rajasekharreddy PalaSurya M Nauli
Nov 23, 2019·Pharmacogenomics·Willian Abraham da SilveiraGary Hardiman
Apr 20, 2020·Acta Biomaterialia·Greeshma ThrivikramanRobert T Tranquillo
Aug 23, 2020·Journal of cardiology·Guy TopazKeren Cohen-Hagai

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