The role of vasopressin in hypothalamo-pituitary-adrenal axis activation during stress: an assessment of the evidence

Annals of the New York Academy of Sciences
Gábor B MakaraDóra Zelena

Abstract

The hypothalamo-pituitary-adrenal (HPA) axis is a key component of the stress reaction. Most contemporary reviews mention the corticotropin-releasing hormone and arginine vasopressin (AVP)-containing parvocellular neurons of the hypothalamic paraventricular nucleus as the endocrinomotor component of the system. Although there are many studies about the role of AVP in the stress activation, there is evidence consistent and inconsistent with the general view on the importance of AVP. We propose a list of experiments that may provide critical evidence for or against the widely held opinion. The naturally AVP-deficient Brattleboro rat seems to be a good tool for studying the role of AVP. Our experiments on Brattleboro rats with restraint and ip hypertonic saline injection did not support the prominent role of AVP in acute stress, although in forced swim the lack of AVP influenced the HPA axis activation. Among different chronic stress situations (14 days' restraint, chronic morphine or ip hypertonic saline treatment, streptozotocin-induced diabetes mellitus), the role of AVP was not confirmed by changes in somatic parameter (i.e., body, thymus, and adrenal weight changes).

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Citations

Apr 25, 2012·Cellular and Molecular Neurobiology·Gábor B MakaraDóra Zelena
Apr 12, 2011·Folia Histochemica Et Cytobiologica·Nebojsa JasnicGordana Cvijic
Dec 9, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Dóra ZelenaGábor B Makara
Nov 26, 2010·Physiology & Behavior·Isabell J SchererRuth B S Harris
Oct 1, 2011·Hormone Molecular Biology and Clinical Investigation·Greti Aguilera
Jun 10, 2016·Psychiatry and Clinical Neurosciences·Roberta CoelhoRodrigo Grassi-Oliveira
Apr 2, 2011·Physiology & Behavior·Jaidee K ZavalaKristin L Gosselink
Apr 6, 2018·Cellular and Molecular Life Sciences : CMLS·Lisa YangWaljit S Dhillo
May 17, 2018·Stress : the International Journal on the Biology of Stress·Julia K GjerstadFrancesca Spiga
Jan 21, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Inga D NeumannAlexa H Veenema
Apr 9, 2020·The Journal of Physiology·Sevil Arabacı TamerBerrak Ç Yeğen
Apr 7, 2007·Endocrinology·Sivan Subburaju, Greti Aguilera
Jul 13, 2019·Frontiers in Endocrinology·Ferenc A Antoni
Dec 4, 2020·International Journal of Molecular Sciences·Hidenori FukuokaYutaka Takahashi
Aug 28, 2021·International Journal of Molecular Sciences·Tiago ChavesDóra Zelena

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