The Role of VE-cadherin in Blood-brain Barrier Integrity Under Central Nervous System Pathological Conditions

Current Neuropharmacology
Wenlu LiHaibin Dai

Abstract

The blood-brain barrier (BBB) is a layer between the blood circulation and neural tissue. It plays a pivotal role in maintaining the vulnerable extracellular microenvironment in the neuronal parenchyma. Neuroinflammatory events can result in BBB dysregulation by disturbing adherens junctions (AJs) and tight junctions (TJs). VE-cadherin, as one of the most important components of the vascular system, is specifically responsible for the assembly of AJs and BBB architecture. Here, we present a review, which highlights recently available insights into the relationship between the neuroinflammation and BBB dysregulation. We then explore the specific interaction between VE-cadherin and BBB. Finally, we discuss the changes of VE-cadherin with different neurological diseases from both experimental and clinical studies. An understanding of VE-cadherin in BBB regulation may indicate that VE-cadherin can partially be a biomarker of neuroinflammation disease and lead to novel approaches for abating BBB dysregulation under pathological conditions and the opening of the BBB following central nervous system (CNS) drug delivery.

Citations

May 18, 2020·The Journal of Comparative Neurology·Miguel A Gama SosaGregory A Elder
Jan 5, 2019·Journal of Cell Science·Jiahui Cao, Hans Schnittler
Apr 3, 2021·CNS Drugs·Reshmi RoyMark S Freedman
Apr 8, 2021·Fluids and Barriers of the CNS·Stephanie A IheziePeeyush Kumar Thankamani Pandit
Jun 29, 2021·Frontiers in Bioengineering and Biotechnology·Juntao WangJia Li
Jun 29, 2021·Frontiers in Cardiovascular Medicine·Somasundaram RaghavanM Dennis Leo

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