The Role of Verb Fluency in the Detection of Early Cognitive Impairment in Alzheimer's Disease

Journal of Alzheimer's Disease : JAD
Montserrat AlegretMercè Boada

Abstract

Verb fluency (VF) is the less commonly used fluency test, despite several studies suggesting its potential as a neuropsychological assessment tool. To investigate the presence of VF deficits in mild cognitive impairment (MCI) and mild Alzheimer's disease (AD) dementia; to assess the usefulness of VF in the detection of cognitively healthy (CH) people who will convert to MCI, and from MCI to dementia; and to establish the VF cut-offs useful in the cognitive assessment of Spanish population. 568 CH, 885 MCI, and 367 mild AD dementia individuals were administered the VF test and a complete neuropsychological battery. Longitudinal analyses were performed in 231 CH and 667 MCI subjects to search for VF predictors of diagnosis conversion. A worsening on VF performance from CH, MCI to AD dementia groups was found. Lower performances on VF were significantly related to conversion from CH to MCI/MCI to dementia. When the effect of time to conversion was analyzed, a significant effect of VF was found on the faster conversion from CH to MCI, but not from MCI to dementia. Moreover, VF cut-off scores and sensitivity/specificity values were calculated for 6 conditions (3 age ranges by 2 educational levels). The VF test may be a useful tool f...Continue Reading

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Citations

Oct 28, 2019·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Priscilla M VásquezHector M González
Dec 14, 2018·Dementia & Neuropsychologia·Andressa Hermes PereiraRochele Paz Fonseca
Jul 26, 2019·Clinical Linguistics & Phonetics·Veronika SvindtIldikó Hoffmann
Feb 14, 2020·Current Alzheimer Research·Ryosuke NagumoHiroyuki Shimada
Mar 12, 2020·Frontiers in Aging Neuroscience·Chia-Hsiung ChengPei-Ning Wang
Aug 4, 2020·Journal of Alzheimer's Disease : JAD·Almudena JunqueraSara Fernández-Guinea
May 4, 2021·Journal of Alzheimer's Disease : JAD·Montserrat AlegretSergi Valero
May 4, 2021·Journal of Alzheimer's Disease : JAD·Daniela SmirniPatrizia Turriziani

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