The role of viral, host, and secondary bacterial factors in influenza pathogenesis

The American Journal of Pathology
John C Kash, Jeffery K Taubenberger

Abstract

Influenza A virus infections in humans generally cause self-limited infections, but can result in severe disease, secondary bacterial pneumonias, and death. Influenza viruses can replicate in epithelial cells throughout the respiratory tree and can cause tracheitis, bronchitis, bronchiolitis, diffuse alveolar damage with pulmonary edema and hemorrhage, and interstitial and airspace inflammation. The mechanisms by which influenza infections result in enhanced disease, including development of pneumonia and acute respiratory distress, are multifactorial, involving host, viral, and bacterial factors. Host factors that enhance risk of severe influenza disease include underlying comorbidities, such as cardiac and respiratory disease, immunosuppression, and pregnancy. Viral parameters enhancing disease risk include polymerase mutations associated with host switch and adaptation, viral proteins that modulate immune and antiviral responses, and virulence factors that increase disease severity, which can be especially prominent in pandemic viruses and some zoonotic influenza viruses causing human infections. Influenza viral infections result in damage to the respiratory epithelium that facilitates secondary infection with common bacteri...Continue Reading

References

Mar 1, 1992·Microbiological Reviews·R G WebsterY Kawaoka
Jul 4, 1998·The Journal of Infectious Diseases·L SimonsenK Fukuda
Mar 29, 2002·Molecular Biology and Evolution·Yoshiyuki Suzuki, Masatoshi Nei
Jul 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·Edwin D KilbourneNancy Cox
Mar 28, 2003·The Journal of Infectious Diseases·Jonathan A McCullers, Kimberly C Bartmess
Aug 17, 2005·Journal of Virology·K M Sturm-RamirezR G Webster
Oct 7, 2005·Nature·Jeffery K TaubenbergerThomas G Fanning
Feb 24, 2006·Emerging Infectious Diseases·Jeffery K Taubenberger, David M Morens
Jul 4, 2006·Antiviral Research·Frederick G Hayden
Jul 19, 2006·Clinical Microbiology Reviews·Jonathan A McCullers
Sep 2, 2006·Molecular Biology and Evolution·Rubing Chen, Edward C Holmes
Nov 17, 2007·Cell Host & Microbe·Gina M Conenello, Peter Palese
Nov 28, 2007·Annual Review of Pathology·Jeffery K Taubenberger, David M Morens
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Claudia PappasTerrence M Tumpey
Jun 3, 2008·PLoS Pathogens·Vivien G DuganJeffery K Taubenberger
Dec 31, 2008·Proceedings of the National Academy of Sciences of the United States of America·Tokiko WatanabeYoshihiro Kawaoka
Feb 21, 2009·Vaccine·Thijs Kuiken, Jeffery K Taubenberger
Jul 1, 2009·The New England Journal of Medicine·David M MorensAnthony S Fauci
Jan 19, 2010·The Journal of Infectious Diseases·Frank R DeLeo, James M Musser
Mar 30, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Matthew J MemoliJeffery K Taubenberger
Mar 31, 2010·The Journal of Infectious Diseases·Matthew J MemoliJeffery K Taubenberger
Jun 15, 2010·Cell Host & Microbe·Jeffery K Taubenberger, John C Kash
Sep 2, 2011·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·E R GauntP Simmonds
Sep 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·Zong-Mei ShengJeffery K Taubenberger
Feb 18, 2012·Influenza and Other Respiratory Viruses·Erik A KarlssonStacey Schultz-Cherry
Jun 23, 2012·Science·Sander HerfstRon A M Fouchier
Nov 23, 2012·Influenza and Other Respiratory Viruses·Matthew J MemoliJeffery K Taubenberger
Jan 17, 2013·JAMA : the Journal of the American Medical Association·Daniel S Chertow, Matthew J Memoli
Mar 26, 2013·Antiviral Research·Mélanie SamsonGuy Boivin
Sep 28, 2013·The Journal of Infectious Diseases·Keven M RobinsonJohn F Alcorn
Nov 5, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Matthew J MemoliJeffery K Taubenberger
Dec 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Zhongfang WangJianqing Xu
Mar 4, 2014·Trends in Microbiology·Ying WuGeorge F Gao

❮ Previous
Next ❯

Citations

Jan 14, 2016·Current Opinion in Immunology·Michael J CiancanelliJean-Laurent Casanova
Apr 21, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jamie F S MannPaul F McKay
Apr 25, 2015·The American Journal of Pathology·James M Musser, Frank R DeLeo
Jun 18, 2016·Emerging Infectious Diseases·Jennifer S McDanelMarin L Schweizer
Aug 10, 2016·The Science of the Total Environment·Xin-Lei GaoJi Li
Oct 17, 2016·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Luciana P TavaresCristiana C Garcia
Dec 17, 2016·Current Opinion in Infectious Diseases·Ignacio Martin-LoechesMarcus J Schultz
May 17, 2018·Physiological Reviews·Lee J QuintonJoseph P Mizgerd
May 23, 2018·Human Vaccines & Immunotherapeutics·Kathrin U Jansen, Annaliesa S Anderson
Jun 2, 2018·Rapid Communications in Mass Spectrometry : RCM·Hanzhi WuZongwei Cai
Sep 27, 2018·American Journal of Public Health·David M Morens, Jeffery K Taubenberger
Oct 5, 2018·Journal of Virology·Elizabeth J FayRyan A Langlois
Jan 10, 2018·Nature Medicine·Kathrin U JansenAnnaliesa S Anderson
Sep 19, 2018·Nature Microbiology·Aartjan J W Te VelthuisErvin Fodor
Feb 5, 2019·The Journal of Infectious Diseases·David M Morens, Jeffery K Taubenberger
Jan 26, 2020·FEMS Microbiology Reviews·Dan I AnderssonTone Tønjum
Aug 31, 2019·The Pediatric Infectious Disease Journal·Aykut EşkiEsen Demir
Jan 10, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Fany BlancMustapha Si-Tahar
Dec 25, 2019·Cold Spring Harbor Perspectives in Medicine·Jeffery K Taubenberger, David M Morens
Sep 9, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Freeman Suber, Lester Kobzik
May 10, 2019·American Journal of Respiratory Cell and Molecular Biology·Sivasami PulavendranNarasaraju Teluguakula
Aug 28, 2020·Frontiers in Medicine·Prasanth ManoharSebastian Leptihn
Jul 12, 2017·Frontiers in Microbiology·Denise E MorrisStuart C Clarke
Dec 19, 2018·Proceedings of the National Academy of Sciences of the United States of America·Keith P Klugman, Steven Black
Mar 20, 2019·Frontiers in Cellular and Infection Microbiology·Wolfgang EisenreichWerner Goebel
Nov 9, 2019·Multidisciplinary Respiratory Medicine·Francesca PuggioniEnrico Heffler
Dec 19, 2018·Proceedings of the National Academy of Sciences of the United States of America·David A Relman, Marc Lipsitch

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

Transplant Infectious Disease : an Official Journal of the Transplantation Society
G ReidD Kumar
© 2022 Meta ULC. All rights reserved