The role of visceral adiposity in the severity of COVID-19: Highlights from a unicenter cross-sectional pilot study in Germany

Metabolism: Clinical and Experimental
Antonia PetersenLisa C Adams

Abstract

Overall obesity has recently been established as an independent risk factor for critical illness in patients with coronavirus disease 2019 (COVID-19). The role of fat distribution and especially that of visceral fat, which is often associated with metabolic syndrome, remains unclear. Therefore, this study aims at investigating the association between fat distribution and COVID-19 severity. Thirty patients with COVID-19 and a mean age of 65.6 ± 13.1 years from a level-one medical center in Berlin, Germany, were included in the present cross-sectional analysis. COVID-19 was confirmed by polymerase chain reaction (PCR) from nasal and throat swabs. A severe clinical course of COVID-19 was defined by hospitalization in the intensive care unit (ICU) and/or invasive mechanical ventilation. Fat was measured at the level of the first lumbar vertebra on routinely acquired low-dose chest computed tomography (CT). An increase in visceral fat area (VFA) by ten square centimeters was associated with a 1.37-fold higher likelihood of ICU treatment and a 1.32-fold higher likelihood of mechanical ventilation (adjusted for age and sex). For upper abdominal circumference, each additional centimeter of circumference was associated with a 1.13-fold ...Continue Reading

Citations

Aug 19, 2020·International Journal of Molecular Sciences·Andreas RitterJuping Yuan
Oct 18, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Mária FöldiUNKNOWN KETLAK study group
Oct 24, 2020·Intensive Care Medicine·Audrey De JongSamir Jaber
Nov 25, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Bruno HalpernOscar H Franco
Jan 5, 2021·Immunity & Ageing : I & a·Sameer MohammadAbderrezak Bouchama
Nov 28, 2020·Metabolism: Clinical and Experimental·Guillaume FavreVincent Esnault
Nov 23, 2020·Metabolism: Clinical and Experimental·Kajetan GrodeckiDamini Dey
Jan 23, 2021·Nature Reviews. Endocrinology·Norbert StefanMatthias B Schulze
Oct 24, 2020·Diabetes Research and Clinical Practice·Thirunavukkarasu Sathish, Nitin Kapoor
Dec 10, 2020·Saudi Journal of Biological Sciences·Saba Al HeialySuad Hannawi
Dec 29, 2020·Obesity Research & Clinical Practice·Federica PediconiFrancesco Sardanelli
Jan 10, 2021·Metabolism: Clinical and Experimental·Léa PietriSophie Béliard
Oct 27, 2020·Frontiers in Endocrinology·Domenico Azzolino, Matteo Cesari
Dec 18, 2020·BMJ Open Respiratory Research·Cathelijne M van ZelstGert-Jan Braunstahl
Feb 16, 2021·Current Opinion in Clinical Nutrition and Metabolic Care·Edda Cava, Salvatore Carbone
Mar 30, 2021·Frontiers in Endocrinology·Danfei LiuLimin Xia
Apr 7, 2021·Eating and Weight Disorders : EWD·Alexis Elias MalavazosGianluca Iacobellis
Apr 17, 2021·Reviews in Endocrine & Metabolic Disorders·Seda Hanife OguzBulent Okan Yildiz
May 1, 2021·Journal of Clinical Medicine·Paula Postigo-MartinJesús Seco-Calvo
May 15, 2021·PloS One·Giulia BesuttiUNKNOWN Reggio Emilia COVID-19 Working Group
May 24, 2021·Academic Radiology·Sungheon Gene Kim
May 28, 2021·International Journal of Endocrinology·Diego Assis GonçalvesJacy Gameiro
May 18, 2021·Frontiers in Endocrinology·Maria Alessandra Gammone, Nicolantonio D'Orazio
Jun 4, 2021·Molecular Metabolism·Sebastian HörberAndreas Peter
Jul 13, 2021·Obesity Medicine·Balázs PorosDominik J Hoechter
Feb 4, 2021·Aging and Disease·Shu LiYaogang Wang
Jul 11, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Katherine M BunnellMiriam A Bredella
Feb 25, 2021·Annals of the American Thoracic Society·Gamze Durhan
Aug 13, 2021·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Ibrahim SahinAlper Sonmez
Aug 15, 2021·Revista Española De Cardiología·Teresa SevillaAlberto San Román
Aug 21, 2021·Scientific Reports·Mohammad A DabbahDiwakar Mohan

❮ Previous
Next ❯

Methods Mentioned

BETA
PCRs

Software Mentioned

AIDR3D
R
[UNK] Advanced Visualization
LUX
Pluristem
Vital
tidyverse
MedPass

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.