The Role of Vitamin D in Brain Health: A Mini Literature Review

Curēus
Ibrar AnjumSheraz Anjum

Abstract

Vitamin D is vital for our body as it regulates calcium homeostasis and maintains bone integrity. In this article, we will discuss how vitamin D aids in the function of neuronal and glial tissue and the many health consequences in a person with vitamin D deficiency. Some of the effects of vitamin D deficiency that will be discussed include the development of dementia caused by the increase of cerebral soluble and insoluble amyloid-β (Aβ) peptides and a decrease of its anti-inflammatory/antioxidant properties, the link to depression by a reduction of the buffering of increased calcium in the brain, and vitamin D deficiency in expecting mothers linking to the development of autism and schizophrenic-like disorders, hypoxic brain injury, and other mental illnesses. Lastly, we will discuss how vitamin D deficiency is linked to the development of diabetes mellitus, its role in neuronal development and a decrease of microglial inflammatory function leading to increased brain infections.

Citations

Jul 19, 2019·Journal of the American College of Nutrition·Maria Gogou, George Kolios
May 10, 2020·International Journal of Environmental Research and Public Health·Birgitta Dresp-Langley
Apr 16, 2020·Current Pharmaceutical Design·Martina SiracusanoLuigi Mazzone
May 14, 2020·Journal of Aging Research·Sadia SultanAmira Hazazi
Dec 12, 2019·Frontiers in Immunology·Farhan CyprianGuillermina Girardi
Jul 8, 2020·Journal of Endocrinological Investigation·L Di LuigiP Sgrò
Jan 6, 2021·Neurotoxicity Research·Hossein HosseiniradNousha Afsharzadeh
Jan 8, 2021·Expert Review of Neurotherapeutics·Francesco PanzaMadia Lozupone
Jan 2, 2021·International Journal of Molecular Sciences·Sophia X SuiJulie A Pasco

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