The role of vitamin D in the control of Leishmania infection

Canadian Journal of Physiology and Pharmacology
Espiridión Ramos-MartínezMónica Irais Villaseñor-Cardoso

Abstract

Vitamin D has been described as an essential element for maintaining the homeostasis of mineral content in the body and bone architecture. However, our view of the physiological functions of this micronutrient has radically changed, owing to the vast number of properties, not calcium-related, mediated by its nuclear receptor. This receptor has been found in a variety of cells, including the immune cells, where many of the functions performed by vitamin D are related to inflammation. Although the effect of vitamin D has been widely studied in many diseases caused by viruses or bacteria, very little is known about its role in parasitic diseases, such as leishmaniasis, which is a vector-borne disease caused by different species of the intracellular parasite Leishmania spp. This disease occurs as a spectrum of different clinical syndromes, all of them characterized by a large amount of tissue damage, sometimes leading to necrosis. Owing to the involvement of vitamin D in inflammation and wound healing, its role in leishmaniasis must be relevant, and could be used as an adjuvant for the control of this parasitic disease, opening a possibility for a therapeutic application.

References

Sep 16, 1983·Science·D M ProvvediniS C Manolagas
Oct 1, 1984·The Journal of Clinical Investigation·W F RigbyM W Fanger
Nov 1, 1983·The Journal of Clinical Investigation·J S AdamsF R Singer
Jan 1, 1995·Archives of Dermatological Research·C Lützow-HolmO P Clausen
Jan 1, 1995·Annual Review of Immunology·S L Reiner, R M Locksley
Jul 1, 1993·Clinical Microbiology Reviews·G Grimaldi, R B Tesh
Jan 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R D Pearson, A Q Sousa
Jan 1, 1997·European Journal of Clinical Pharmacology·J R SnymanD J Lizamore
Dec 22, 1999·Advances in Immunology·W Solbach, T Laskay
Dec 23, 1999·Current Opinion in Hematology·M M Kane, D M Mosser
Jun 20, 2000·Parasitology Today·M G Rittig, C Bogdan
Jun 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·D E JonesP Scott
Jan 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M M Kane, D M Mosser
Apr 9, 2001·Clinical Microbiology Reviews·E Handman
Feb 28, 2002·The Journal of Infectious Diseases·Claudine Matte, Martin Olivier
Mar 14, 2002·Experimental and Molecular Pathology·Anna C Cunningham
Apr 17, 2002·Lancet·Chantal MathieuRoger Bouillon
Jul 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eresso AgaTamás Laskay
Jul 26, 2002·The American Journal of Tropical Medicine and Hygiene·Fabiola Aguilar TorrenteraYves Carlier
Nov 5, 2002·Nature Reviews. Immunology·David Sacks, Nancy Noben-Trauth
Dec 9, 2004·The American Journal of Clinical Nutrition·Hector F DeLuca
Apr 16, 2005·Clinical Microbiology Reviews·Martin OlivierGeneviève Forget
Oct 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Anuratha SakthianandeswarenSimon J Foote
Nov 1, 2005·Lancet·Henry W MurrayNancy G Saravia
Apr 25, 2006·Parasitology Research·C M Lezama-Davila, A P Isaac-Marquez
Jul 11, 2006·The American Journal of Clinical Nutrition·Heike A Bischoff-FerrariBess Dawson-Hughes
Dec 6, 2006·Immunology and Cell Biology·Amanda C Stanley, Christian R Engwerda
Jan 16, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Adrian R MartineauChristopher J Griffiths
Jun 7, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jan EhrchenAndreas Lengeling
Aug 24, 2007·The Lancet Infectious Diseases·Richard ReithingerSimon Brooker
Oct 16, 2008·The Journal of Clinical Endocrinology and Metabolism·Daniel Bikle
Dec 2, 2008·Experimental Parasitology·Leonardo Valdés-ReyesLaila Gutiérrez-Kobeh

❮ Previous
Next ❯

Citations

Sep 23, 2020·Parasitology·Patrícia de Almeida MachadoHerbert Leonel de Matos Guedes
Oct 12, 2020·Cytokine·Abdollah JafarzadehMaryam Nemati

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Parasitology Research
Jutta Klasen, Birgit Habedank
International Journal of Dermatology
Maria Rita BongiornoMario Aricò
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
R D Pearson, A Q Sousa
© 2021 Meta ULC. All rights reserved