The role of vitamin E in atherogenesis: linking the chemical, biological and clinical aspects of the disease

Atherosclerosis
Jiri NeuzilAnatol Kontush

Abstract

Atherosclerosis is a disease involving both oxidative modifications and disbalance of the immune system. Vitamin E, an endogenous redox-active component of circulating lipoproteins and (sub)cellular membranes whose levels can be manipulated by supplementation, has been shown to play a role in the initiation and progression of the disease. Recent data reveal that the activities of vitamin E go beyond its redox function. Moreover, it has been shown that vitamin E can exacerbate certain processes associated with atherogenesis. In this essay we review the role of biology of atherosclerosis, and suggest that these two facets decide the clinical manifestation and outcome of the disease.

References

Oct 1, 1977·Journal of Dental Research·L R BrownD A Johnston
Apr 1, 1977·American Heart Journal·R E GillilanJ R Warbasse
Dec 1, 1992·The Journal of Experimental Medicine·A S NeishT Collins
May 1, 1992·The Journal of Experimental Medicine·R SchreckP A Baeuerle
Oct 1, 1992·Free Radical Biology & Medicine·H EsterbauerG Jürgens
Jan 1, 1992·Free Radical Biology & Medicine·H Kappus, A T Diplock
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S Ylä-HerttualaD Steinberg
Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D J ConradE Sigal
Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·R StockerB Frei
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J S BeckmanB A Freeman
Jan 1, 1990·Free Radical Biology & Medicine·U P SteinbrecherM Lougheed
Jan 1, 1989·Free Radical Research Communications·H EsterbauerM Rotheneder
May 1, 1989·The British Journal of Nutrition·S L GodfriedL A Dillingham
Mar 1, 1986·The Journal of Clinical Investigation·J W HeineckeA Chait
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·B FreiB N Ames
May 1, 1987·The American Journal of Clinical Nutrition·K F GeyH B Stähelin
Feb 1, 1987·The American Journal of Clinical Nutrition·F J KokH A Valkenburg
Jan 1, 1987·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M E RosenfeldR Ross
Oct 20, 1995·Archives of Biochemistry and Biophysics·L KritharidesR T Dean
Dec 1, 1995·The American Journal of Clinical Nutrition·A AzziA Tasinato
Dec 1, 1995·The American Journal of Clinical Nutrition·S R ThomasR Stocker
Aug 1, 1994·The Journal of Clinical Investigation·R FaruqiP E DiCorleto
Oct 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·C SuarnaR Stocker

❮ Previous
Next ❯

Citations

Dec 8, 2004·Molecular Nutrition & Food Research·Claus Schneider
Mar 4, 2008·Journal of Physiology and Biochemistry·M CiocoiuI Paduraru
Nov 26, 2008·Bulletin of Experimental Biology and Medicine·L B DudnikM A Pokrovskaya
Dec 23, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ntei AbuduStanley S Levinson
Mar 5, 2004·Chemistry and Physics of Lipids·Janko N HerakDubravka Krilov
Mar 5, 2004·Chemistry and Physics of Lipids·Dubravka KrilovJanko N Herak
Jan 19, 2002·Biochemical and Biophysical Research Communications·Kristina JostarndtJiri Neuzil
May 23, 2002·FEBS Letters·Angelo AzziJean Marc Zingg
Mar 24, 2009·Metabolism: Clinical and Experimental·Absalon D GutierrezDavid S Schade
Mar 9, 2005·Annals of the New York Academy of Sciences·Kanatol Kontush, Svetlana Schekatolina
Oct 12, 2013·Redox Report : Communications in Free Radical Research·Clara A VelosoMíriam M Chaves
Feb 1, 2008·Expert Opinion on Drug Discovery·Anatol Kontush, Svetlana Schekatolina
Sep 28, 2006·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Irina RobinsonDavid S Schade
Jun 16, 2005·Biochimica Et Biophysica Acta·Namakkal Soorappan RajasekaranHalagowder Devaraj
Feb 18, 2006·Free Radical Research·Ntei AbuduStanley S Levinson
Aug 21, 2008·Critical Reviews in Clinical Laboratory Sciences·Michael W ClarkeKevin D Croft
Jul 9, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Anatol KontushRoland Stocker
Feb 26, 2003·Circulation·Riitta M SalonenUNKNOWN Antioxidant Supplementation in Atherosclerosis Prevention Study
Sep 27, 2002·The American Journal of Clinical Nutrition·Regina Brigelius-FlohéAngelo Azzi
Sep 22, 2007·The Journal of Nutrition·Yi Li, Herb E Schellhorn
Mar 14, 2002·Current Opinion in Lipidology·Robert Cramb
Mar 28, 2009·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Heidi SchusterJean-Pascal De Bandt

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.