The role of vitamin E in reversing bone loss

Aging Clinical and Experimental Research
Sheau C ChaiB H Arjmandi

Abstract

A positive correlation between intake of antioxidants including vitamins E and C on bone mass has been established by a number of investigators. The present study was conducted to evaluate the extent to which higher doses of vitamin E than normal dose (75 IU per kg diet) can reverse bone loss in aged osteopenic orchidectomized male rats. Forty 12-month old male Sprague- Dawley rats were either sham-operated (Sham) or orchidectomized (Orx), and fed control diet for 120 days to establish bone loss. Thereafter, rats were assigned to their corresponding treatment groups (n= 10 per group): Sham and one Orx groups received 75 IU vitamin E and served as controls, and the other two Orx groups received either 250 or 500 IU vitamin E per kg diet for 90 days. Higher doses of vitamin E did not improve bone mineral density (BMD) or content (BMC) of whole body, femur and lumbar vertebra or alter the orchidectomy-induced deterioration of trabecular microarchitecture of the distal femur metaphysis in comparison with Orx controls that received adequate vitamin E. Biochemical markers of bone formation and bone resorption, i.e. serum osteocalcin and urinary deoxypyridinoline crosslinks, were also unaffected by vitamin E supplementation. Overall, ...Continue Reading

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Citations

Oct 4, 2013·Journal of Osteoporosis·Rafaela G FeresinBahram H Arjmandi
Dec 27, 2015·Pharmacology & Therapeutics·Hong Yong PehW S Fred Wong
Feb 7, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Maryam S HamidiAngela M Cheung
Nov 3, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Isa Naina MohamedNur Farhana Mohd Fozi
Oct 25, 2012·Journal of Osteoporosis·Mercedes MonteroConcepción de la Piedra
Aug 29, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Saif Abdul-MajeedIma-Nirwana Soelaiman
May 18, 2018·Clinical Orthopaedics and Related Research·Arianna B LovatiCarlo L Romanò
Mar 1, 2016·Food & Function·Sarah A JohnsonBahram H Arjmandi
Oct 26, 2018·PloS One·Sheau C ChaiBahram H Arjmandi
Mar 27, 2019·International Journal of Molecular Sciences·Sok Kuan WongSoelaiman Ima-Nirwana
Sep 8, 2019·Nutrients·Kun-Mo LinKuo-Cheng Lu
Apr 10, 2018·Clinical Orthopaedics and Related Research·Jessica Amber Jennings

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