The role of vitronectin as multifunctional regulator in the hemostatic and immune systems.

Blut
K T Preissner

Abstract

Vitronectin (= complement S-protein) belongs to the group of structurally and functionally homologous adhesive proteins (fibrinogen, fibronectin, von Willebrand factor) which are essential in the procoagulant phase of the hemostatic system, interacting with platelets and the vessel wall. In addition to a structural motif in vitronectin responsible for this interaction (cell attachment domain) other functional domains in the protein molecule exist that contribute to its multifunctional role as regulator in the immune system (complement) as well as in fibrinolysis. These various activities and the ubiquitous distribution of vitronectin in the organism are discussed with regard to structure-function relationships of the protein molecule. Vitronectin may thus provide a conceptual molecular link between cell adhesion, humoral immune response and the hemostatic system, particularly at the blood-vessel wall interphase.

References

Jun 1, 1978·The Journal of Experimental Medicine·E A Jaffe, D F Mosher
Aug 1, 1978·Experimental Cell Research·F Grinnell, D G Hays
Jan 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·L B Chen, J M Buchanan
Jan 29, 1986·Biochemical and Biophysical Research Communications·K T PreissnerG Müller-Berghaus
Feb 28, 1986·Cell·E Ruoslahti, M D Pierschbacher
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J Tschopp, T E Mollnes
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·L S ZalmanH J Müller-Eberhard
Jan 1, 1987·Methods in Enzymology·E RuoslahtiM D Pierschbacher
Mar 1, 1988·The Journal of Cell Biology·K R GehlsenE Ruoslahti
Apr 1, 1988·Cell Structure and Function·K KubotaM Hayashi
Nov 30, 1988·Biochemical and Biophysical Research Communications·D C SaneC S Greenberg
Dec 30, 1988·Biochemical and Biophysical Research Communications·B Korc-GrodzickiS Shaltiel
Feb 24, 1989·Biochimica Et Biophysica Acta·M IzumiM Hayashi
Jan 1, 1989·Scandinavian Journal of Immunology·G HetlandE Johnson
Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·C GuettierJ P Camilleri
Oct 23, 1987·Science·E Ruoslahti, M D Pierschbacher
Oct 1, 1987·Seminars in Thrombosis and Hemostasis·J A Marcum, R D Rosenberg
Jan 1, 1988·Annual Review of Biochemistry·E Ruoslahti
Jan 1, 1986·Annual Review of Immunology·H J Müller-Eberhard

❮ Previous
Next ❯

Citations

Apr 12, 2000·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·A Sagripanti, A Carpi
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·F P ReinholtD Heinegård
Oct 1, 1996·The Journal of Experimental Medicine·P MarshallM Whitlow
Jul 1, 1992·Scandinavian Journal of Immunology·V BergeG Hetland
Dec 15, 1993·European Journal of Biochemistry·A YonedaN Seno
Jun 15, 1995·European Journal of Biochemistry·H OgawaI Matsumoto
Jul 1, 1996·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·V BergeE Johnson
Feb 1, 1993·The American Review of Respiratory Disease·H TeschlerS I Rennard
Jul 1, 1992·Journal of Periodontology·B SteffensenR J Klebe
Jun 1, 1990·Immunität und Infektion·S BhakdiJ Tranum-Jensen
Sep 21, 1994·Biochimica Et Biophysica Acta·O Sigurdardottir, B Wiman
Feb 6, 2004·Journal of Biomedical Materials Research. Part a·Hailong ZhangRoger St C Smart
Oct 6, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Shin-ichiro ArimuraIkuro Maruyama
Jan 31, 1991·Biochemical and Biophysical Research Communications·D C SaneC S Greenberg
Dec 31, 1997·Clinics in Chest Medicine·U Costabel, H Teschler
Dec 24, 2013·Biochimica Et Biophysica Acta·Cédric ZeltzDonald Gullberg
Jan 1, 1994·Journal of Biomaterials Science. Polymer Edition·T GrothG Altankov
Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuko TsurutaEdward Abraham
May 24, 2019·BMC Cancer·Rebeca Burgos-PanaderoRosa Noguera
Jan 1, 1991·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·S B MilamB Steffenson
Jul 1, 1995·Clinical and Experimental Immunology·M SheehanJ A Charlesworth
Jun 1, 1990·Blut·S BhakdiJ Tranum-Jensen
Feb 1, 1996·The Journal of Investigative Dermatology·Z S ChenR A Swerlick
Dec 1, 1992·The Journal of Investigative Dermatology·R A SwerlickT J Lawley

❮ Previous
Next ❯

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