The role of volumetric ADC histogram analysis in preoperatively evaluating the tumour subtype and grade of endometrial cancer.

European Journal of Radiology
Xiaoliang MaJ W Qiang

Abstract

To assess the value of volumetric ADC histogram metrics in evaluating the histological subtype and grade of endometrial cancer. Preoperative MRI datasets of 317 patients with endometrial cancer were used to obtain volumetric ADC histogram metrics (tumour volume; minADC, maxADC and meanADC; 10th, 25th, 50th, 75th and 90th percentiles of ADC; skewness; and kurtosis). The Mann-Whitney test or Student's t-test was used to compare the difference in ADC histogram metrics between endometrioid adenocarcinomas (EACs) and serous endometrial cancers (SECs) and between different tumour grades (G1, G2, G3). The area under the curve (AUC) of the receiver operating characteristic (ROC) curve was used to evaluate the performance of ADC histogram metrics or combined models in predicting the tumour subtype and grade. SECs showed a significantly larger tumour volume (P < 0.001) and lower meanADC, 50th, 75th and 90th percentiles of ADC than EACs (all P < 0.05). MinADC, maxADC, meanADC, 10th, 25th, 50th, 75th, 90th percentiles of ADC were significantly higher in G1 than in G2 and G3 EACs (all P < 0.05), while were not significantly different between G2 and G3 EACs (all P > 0.05). A tumour volume ≥ 7.752 cm3 allowed for the prediction of SECs, with ...Continue Reading

References

Aug 9, 2005·Lancet·Frederic AmantIgnace Vergote
Aug 31, 2007·Journal of Magnetic Resonance Imaging : JMRI·Ken TamaiKaori Togashi
Feb 4, 2009·Neoplasia : an International Journal for Oncology Research·Anwar R PadhaniPeter L Choyke
May 19, 2009·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Charlotte S WhittakerAnwar R Padhani
Aug 9, 2011·European Radiology·Doenja M J LambregtsRegina G H Beets-Tan
Sep 8, 2011·The British Journal of Radiology·N BharwaniA G Rockall
Jan 27, 2012·Best Practice & Research. Clinical Obstetrics & Gynaecology·Vivek Arora, Michael A Quinn
Mar 12, 2013·Gynecologic Oncology·Yukiharu TodoNoriaki Sakuragi
Dec 5, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N ColomboUNKNOWN ESMO-ESGO-ESTRO Endometrial Consensus Conference Working Group
Apr 8, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·T P BatistaA L R Bezerra
Sep 9, 2017·Obstetrics and Gynecology·Nicole C M VisserJohanna M A Pijnenborg
Sep 26, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Shifeng TianQiang Wei
Apr 27, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Hilal SahinMuzaffer Sanci
May 29, 2018·European Journal of Radiology·Matteo BonattiGiampietro Bonatti
Jul 12, 2018·European Radiology·Stephanie NougaretRosemarie Forstner
Jan 9, 2019·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

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