The Role of Water Compartments in the Material Properties of Cortical Bone

Calcified Tissue International
Mathilde GrankeJeffry S Nyman

Abstract

Comprising ~20% of the volume, water is a key determinant of the mechanical behavior of cortical bone. It essentially exists in two general compartments: within pores and bound to the matrix. The amount of pore water-residing in the vascular-lacunar-canalicular space-primarily reflects intracortical porosity (i.e., open spaces within the matrix largely due to Haversian canals and resorption sites) and as such is inversely proportional to most mechanical properties of bone. Movement of water according to pressure gradients generated during dynamic loading likely confers hydraulic stiffening to the bone as well. Nonetheless, bound water is a primary contributor to the mechanical behavior of bone in that it is responsible for giving collagen the ability to confer ductility or plasticity to bone (i.e., allows deformation to continue once permanent damage begins to form in the matrix) and decreases with age along with fracture resistance. Thus, dehydration by air-drying or by solvents with less hydrogen bonding capacity causes bone to become brittle, but interestingly, it also increases stiffness and strength across the hierarchical levels of organization. Despite the importance of matrix hydration to fracture resistance, little is ...Continue Reading

References

Apr 15, 1979·Journal of Molecular Biology·R D FraserE Suzuki
Feb 1, 1977·Biopolymers·S NomuraE Baer
May 31, 1977·Calcified Tissue Research·P A Timmins, J C Wall
Feb 1, 1992·Biopolymers·Y A LazarevV S Grechishko
Jul 1, 1990·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·T S KellerD M Spengler
Jan 1, 1989·Matrix : Collagen and Related Research·J KoppJ P Renou
Jul 1, 1967·Physics in Medicine and Biology·A A MarinoC H Bachman
Jan 1, 1981·Calcified Tissue International·S Lees
Oct 25, 1981·Journal of Molecular Biology·K OkuyamaM Kakudo
Jul 1, 1995·Journal of Biomechanics·N Sasaki, A Enyo
Nov 1, 1993·Journal of Biomechanical Engineering·J J BrozM W Luttges
Sep 15, 1995·Structure·J BellaH M Berman
Jun 2, 2000·Journal of Biomechanical Engineering·E GarnerR Brand
May 8, 2001·Journal of Biomedical Materials Research·D H PashleyF A Rueggeberg
Jul 14, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·V BoussonJ D Laredo
Oct 18, 2001·Biomaterials·P LucksanasomboolM V Swain
Dec 26, 2001·Biophysical Journal·Maria A Fernández-SearaFelix W Wehrli
Jan 12, 2002·Journal of Biomedical Materials Research·Junro YamashitaC Mauli Agrawal
Feb 5, 2003·Clinical Radiology·P D Gatehouse, G M Bydder
Feb 6, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Xiaodu Wang, Qingwen Ni
May 14, 2003·Dental Materials : Official Publication of the Academy of Dental Materials·David H PashleyTerry E Callison
May 17, 2003·Science·Gyunggoo ChoJerome L Ackerman
Jul 10, 2003·Magnetic Resonance Imaging·Paola FantazziniGiulio Cesare Borgia
Nov 1, 1952·The American Journal of Anatomy·W T DEMPSTER, R T LIDDICOAT
Mar 1, 1951·Journal of Applied Physiology·F G EVANS, M LEBOW
Feb 19, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Maria A Fernández-SearaFelix W Wehrli
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·J Y Rho, G M Pharr
Jan 27, 2005·Journal of Molecular Biology·Christopher A MilesAllen J Bailey
Feb 16, 2005·Annals of Biomedical Engineering·Michael A K Liebschner, Tony S Keller
Mar 15, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Erin E WilsonLarry W Beck
Apr 20, 2005·Advances in Protein Chemistry·Barbara Brodsky, Anton V Persikov
Jul 30, 2005·Magnetic Resonance Imaging·Ines L H ReichertGraeme M Bydder
Feb 21, 2006·Journal of Biomechanics·Jeffry S NymanXiaodu Wang
Oct 26, 2006·Journal of Dental Research·R K NallaR O Ritchie

❮ Previous
Next ❯

Citations

Jan 26, 2016·Bone·Nadja Fratzl-ZelmanFrank Rauch
Feb 4, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Sandra MurciaD Arola
Oct 22, 2015·Kidney International·Christopher L NewmanMatthew R Allen
Nov 28, 2015·Bone·Sasidhar UppugantiJeffry S Nyman
Dec 29, 2015·Matrix Biology : Journal of the International Society for Matrix Biology·Alycia G BermanMatthew R Allen
Dec 15, 2015·The Journal of Physical Chemistry. C, Nanomaterials and Interfaces·Farhana Gul-E-NoorGregory S Boutis
Jan 11, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E P PaschalisP Fratzl
Sep 1, 2016·BoneKEy Reports·Uwe Wolfram, Jakob Schwiedrzik
Sep 15, 2016·Current Osteoporosis Reports·D M L CooperJ D Johnston
Oct 8, 2016·Current Osteoporosis Reports·Dieter H Pahr, Philippe K Zysset
Nov 1, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Eleftherios P PaschalisCarolina A Moreira
Jul 22, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M W ArefM R Allen
Apr 6, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E P PaschalisK Klaushofer
Apr 25, 2017·Journal of Proteome Research·Noemi ProcopioMichael Buckley
Sep 22, 2018·Advanced Healthcare Materials·Daniel de Melo Pereira, Pamela Habibovic
Nov 12, 2019·Journal of Magnetic Resonance Imaging : JMRI·Anahita Fathi KazerooniAlejandro F Frangi
Sep 11, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hyo Min LeeKlaas Paul Pruessmann
Nov 28, 2019·Scientific Reports·Emmanuelle LefèvreHélène Follet
Jul 2, 2019·Climacteric : the Journal of the International Menopause Society·A A F CarbonelM J B C Girão
Jan 21, 2020·Journal of Biophotonics·No'ad ShanasNancy Pleshko
Sep 5, 2019·The Journal of Bone and Joint Surgery. American Volume·Jerry Y DuClare M Rimnac
Apr 29, 2020·The Analyst·Ramyasri AilavajhalaNancy Pleshko
Sep 25, 2017·Clinical Reviews in Bone and Mineral Metabolism·Heather B Hunt, Eve Donnelly
Jan 20, 2018·Current Osteoporosis Reports·Liyun Wang
Sep 7, 2018·Current Osteoporosis Reports·Sabashini K Ramchand, Ego Seeman
Oct 16, 2018·Biomedical Optics Express·Cesar G Tavera RuizFernando Mendoza Santoyo
Dec 28, 2019·Materials·Amadeus C S de AlcântaraPaulo Sollero
Apr 4, 2018·Current Osteoporosis Reports·Mustafa UnalJeffry S Nyman
Dec 22, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Tan GuoJiang Du
Jul 17, 2019·Scientific Reports·Ramyasri AilavajhalaNancy Pleshko
Sep 7, 2019·F1000Research·Eleftherios P PaschalisMarkus A Hartmann
Aug 8, 2020·Magnetic Resonance in Chemistry : MRC·Nidhi TiwariNeeraj Sinha
Dec 23, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Marco BarbieriLeonardo Brizi
Dec 12, 2020·Acta Biomaterialia·Nouf AldegaitherFinn Giuliani
Feb 13, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·William QueridoNancy Pleshko
Dec 5, 2020·Journal of Functional Biomaterials·Ahmed IbrahimZ Abdel Hamid

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.