The role played by cell-substrate interactions in the pathogenesis of osteoclast-mediated peri-implant osteolysis.

Arthritis Research & Therapy
Zhenxin ShenSteven R Goldring

Abstract

Prosthetic wear debris-induced peri-implant osteolysis is a major cause of aseptic loosening after total joint replacement. In this condition, wear particles released from the implant components induce a granulomatous inflammatory reaction at the interface between implant and adjacent bone, leading to progressive bone resorption and loss of fixation. The present study was undertaken to characterize definitively the phenotype of osteoclast-like cells associated with regions of peri-implant focal bone resorption and to compare the phenotypic features of these cells with those of mononucleated and multinucleated cells associated with polyethylene wear particles. Peri-implant tissues were obtained from patients undergoing hip revision surgery for aseptic loosening after total joint replacement. Cells were examined for the expression of several markers associated with the osteoclast phenotype using immunohistochemistry, histochemistry, and/or in situ hybridization. CD68 protein, a marker expressed by multiple macrophage lineage cell types, was detected in mononucleated and multinucleated cells associated with polyethylene particles and the bone surface. Cathepsin K and tartrate-resistant acid phosphatase were expressed highly in bot...Continue Reading

References

Feb 1, 1988·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S R GoldringJ Glowacki
Aug 1, 1986·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J GlowackiS Goldring
Jan 1, 1986·The Journal of Arthroplasty·G S KantorJ P Conaty
Apr 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D M ShinarM Weinreb
May 1, 1996·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Y KadoyaM A Freeman
Dec 1, 1995·Matrix Biology : Journal of the International Society for Matrix Biology·Z ShenY Sommarin
Jul 1, 1997·Annals of the Rheumatic Diseases·A SabokbarN A Athanasou
Sep 22, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M GowenI Kola
Nov 24, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S D NealeN A Athanasou
Jan 6, 2000·Acta Orthopaedica Scandinavica·S D Neale, N A Athanasou
Feb 29, 2000·Arthritis and Rheumatism·E M GravalleseS R Goldring
Aug 22, 2000·The Journal of Pathology·T J Chambers
Sep 1, 2000·Science·S L Teitelbaum
Jan 10, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M TakagiY T Konttinen
Oct 5, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Y T KonttinenS Santavirta
Feb 22, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Edward M GreenfieldR Renee Van De Motter
Mar 3, 2004·Drug News & Perspectives·Bruce R Troen
Apr 28, 2004·Biomaterials·D R HaynesH Zreiqat
Oct 12, 2004·Biomaterials·Eileen Ingham, John Fisher
Mar 16, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jami MandelinYrjö T Konttinen

❮ Previous
Next ❯

Citations

Nov 24, 2011·Endocrinology·Shinichiro KuroshimaJunro Yamashita
Sep 21, 2012·Canadian Journal of Surgery. Journal Canadien De Chirurgie·Shahryar Noordin, Bassam Masri
Sep 26, 2013·The Journal of Oral Implantology·Pablo Galindo-MorenoFrancisco O'Valle
Feb 27, 2008·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Gloria Amparo Flórez-MorenoSergio Iván Tobón-Arroyave
Sep 8, 2009·Trends in Cell Biology·Laura Helming, Siamon Gordon
Nov 19, 2014·World Journal of Orthopedics·Christoph H LohmannGottfried H Buchhorn
Aug 16, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Kyung-Hyun Park-MinLionel B Ivashkiv
Sep 11, 2014·Journal of Biomedical Materials Research. Part a·Andreas DryndaChristoph H Lohmann
Aug 31, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Panagiotis KoulouvarisP Edward Purdue
Oct 18, 2007·Journal of Biomedical Materials Research. Part a·M JägerR Krauspe
Jan 12, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Lucia SavarinoNicola Baldini
Mar 28, 2008·Autoimmunity·P Edward Purdue
Sep 27, 2014·Clinical Implant Dentistry and Related Research·Ricardo TrindadeAnn Wennerberg
Oct 11, 2015·Annals of the Rheumatic Diseases·Aránzazu MedieroBruce N Cronstein
Feb 24, 2011·Journal of Cellular Physiology·Tania N CrottiKevin P McHugh
Aug 10, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Andreas DryndaChristoph H Lohmann
Mar 7, 2017·Frontiers in Endocrinology·Justin T SmithErin L Hsu
Jun 15, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Douglas E JamesP Edward Purdue
Oct 24, 2007·Biochimica Et Biophysica Acta·Zhenxin ShenKevin P McHugh

❮ Previous
Next ❯

Methods Mentioned

BETA
in vitro transcription
light microscopy

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.