The roles of adenosine in regulating the respiratory and cardiovascular systems in chronically hypoxic, adult rats

The Journal of Physiology
T Thomas, J M Marshall

Abstract

1. We have investigated the roles of adenosine in regulating the respiratory and cardiovascular systems of rats that were made chronically hypoxic for 3-4 weeks from 6 weeks of age (CH rats) in an hypoxic chamber at 12% O2. They were studied under anaesthesia while breathing 12% O2 and during acute hypoxia (breathing 8% O2 for 5 min) before and after addition of the adenosine receptor antagonist 8-phenyltheophylline (8-PT, 10 mg kg-1). The results were compared with those obtained from normoxic (N) rats in a previous study. 2. CH rats breathing 12% O2 had greater minute ventilation (VP) than N rats breathing air, but their levels of arterial blood pressure (ABP), heart rate (HR), femoral vascular conductance (FVC) and cerebral vascular conductance (CVC) were fully comparable. 8-PT increased tidal volume (VT) in CH rats indicating a greater tonic central inhibitory influence of adenosine on VT than in N rats. However, 8-PT had no effect on cardiovascular variables, indicating no tonic cardioinhibitory or vasodilator influence of adenosine in CH rats. 3. Acute hypoxia in CH rats increased VE such that at the 5th minute of 8% O2 absolute VE was comparable to that of N rats breathing 8% O2. Moreover, in CH rats 8-PT increased VT at...Continue Reading

References

May 1, 1978·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·E B Olson, J A Dempsey
Dec 1, 1988·The Journal of Physiology·J M Marshall, J D Metcalfe
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Citations

Jul 11, 2003·Respiratory Physiology & Neurobiology·Karen A Waters, David Gozal
May 13, 2006·The Journal of Physiology·Martin P Walsh, Janice M Marshall
May 13, 2006·The Journal of Physiology·Martin P Walsh, Janice M Marshall
Nov 26, 2015·Respiratory Physiology & Neurobiology·Dirk HeitzmannJoerg Thomas
Feb 1, 2006·Acta Psychiatrica Scandinavica. Supplementum·T BurnsC Wright
Aug 12, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J M Marshall
May 14, 2005·Journal of Applied Physiology·Matthew J CampenChristopher P O'Donnell
Jun 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·D DeveciS Egginton

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