The Roles of Autophagy in Acute Lung Injury Induced by Myocardial Ischemia Reperfusion in Diabetic Rats

Journal of Diabetes Research
Liying ZhanShaoqing Lei

Abstract

Patients with diabetes are vulnerable to myocardial ischemia reperfusion (IR) injury, which may also induce acute lung injury (ALI) due to overaccumulation of reactive oxygen species (ROS) and inflammation cytokine in circulation. Despite autophagy plays a significant role in diabetes and pulmonary IR injury, the role of autophagy in ALI secondary to myocardial IR in diabetes remains largely elusive. We aimed to investigate pulmonary autophagy status and its roles in oxidative stress and inflammation reaction in lung tissues from diabetic rats subjected to myocardial IR. Control or diabetic rats were either treated with or without autophagy inducer rapamycin (Rap) or autophagy inhibitor 3-methyladenine (3-MA) before myocardial IR, which was achieved by occluding the left anterior descending coronary artery for 30 min and followed by reperfusion for 120 min. Diabetic rats subjected to myocardial IR showed more serious ALI with higher lung injury score and WET/DRY ratio and lower PaO2 as compared with control rats, accompanied with impaired autophagy indicated by reduced LC-3II/LC-3I ratio and Beclin-1 expression, decreased superoxide dismutase (SOD) activity, and increased 15-F2t-Isoprostane formation in lung tissues, as well as...Continue Reading

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Citations

Jan 16, 2019·Inflammation·Hongying ZhaoYonghao Yu
Nov 16, 2019·The Journal of Pharmacy and Pharmacology·Wanqiu WangFengjie Huang
Nov 28, 2019·Therapeutic Advances in Respiratory Disease·Shi-Xia LiaoYao Ou-Yang
Jan 12, 2022·Journal of Cellular and Molecular Medicine·Minjian KongAiqiang Dong

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Methods Mentioned

BETA
Broncho
protein assay
electrophoresis
light microscopy

Software Mentioned

GraphPad
GraphPad Prism

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