The roles of CC2D1A and HTR1A gene expressions in autism spectrum disorders

Metabolic Brain Disease
Elif Funda SenerYusuf Ozkul

Abstract

Classical autism belongs to a group of heterogeneous disorders known as autism spectrum disorders (ASD). Autism is defined as a neurodevelopmental disorder, characterized by repetitive stereotypic behaviors or restricted interests, social withdrawal, and communication deficits. Numerous susceptibility genes and chromosomal abnormalities have been reported in association with autism but the etiology of this disorder is unknown in many cases. CC2D1A gene has been linked to mental retardation (MR) in a family with a large deletion before. Intellectual disability (ID) is a common feature of autistic cases. Therefore we aimed to investigate the expressions of CC2D1A and HTR1A genes with the diagnosis of autism in Turkey. Forty-four autistic patients (35 boys, 9 girls) and 27 controls were enrolled and obtained whole blood samples to isolate RNA samples from each participant. CC2D1A and HTR1A gene expressions were assessed by quantitative Real-Time PCR (qRT-PCR) in Genome and Stem Cell Center, Erciyes University. Both expressions of CC2D1A and HTR1A genes studied on ASD cases and controls were significantly different (p < 0.001). The expression of HTR1A was undetectable in the ASD samples. Comparison of ID and CC2D1A gene expression ...Continue Reading

Associated Clinical Trials

Apr 29, 2021·Yusuf Ozkul, Yusuf Ozkul

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Citations

Nov 14, 2019·Neuromolecular Medicine·Halime DanaElif Funda Sener
Dec 9, 2020·The International Journal of Neuroscience·Elif Funda SenerDidem Behice Oztop
Jun 17, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Cheng-Yi YangKuei-Sen Hsu

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