PMID: 26796304Jan 23, 2016Paper

The Roles of Chromatin Remodeling Proteins in Cancer

Current Protein & Peptide Science
Chun ZhangPingyu Zhang

Abstract

Chromatin remodeling complexes (chromatin remodelers) have been demonstrated as essential and powerful regulators for critical DNA-templated cellular processes, such as DNA replication, recombination, gene transcription/repression, and DNA damage repair. These molecular and genetic processes are important for a wide spectrum of cellular functions including, cell cycle, death, differentiation, pluripotency, and genome integrity. Not surprisingly, dysfunctions of chromatin remodeling proteins are observed in human developmental disorders and diseases. Specifically for human malignancies, genomic sequence analyses show that mutations and other genetic alternations of chromatin remodelers exist in almost all human tumor types. Using human cancer cell lines, xenograft models and genetically engineered mouse models, functions of chromatin remodelers in human cancers have been studied extensively in the last 10-15 years. In this review, we summarize the functional and mechanistic studies of chromatin remodelers in the initiation, progression and metastasis of human cancers.

Citations

Jun 6, 2020·Molecular Cancer Therapeutics·Joshua M AbbottDaniel V LaBarbera
Nov 12, 2020·The Science of the Total Environment·Jixiang WangRuiyan Niu
Nov 24, 2016·Biophysical Chemistry·Vaclav UrbanPavel Janscak

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