PMID: 9552399Jan 1, 1996Paper

The roles of DNA topoisomerase II during the cell cycle

Progress in Cell Cycle Research
A K LarsenK Bojanowski

Abstract

DNA topoisomerase II (topo II) is essential for survival of all eukaryotic cells. Topo II is both an enzyme and a structural component of the nuclear matrix. It regulates the topological states of DNA by transient cleavage, strand passing and re-ligation of double-stranded DNA resulting in decatenation of intertwined DNA molecules and relaxation of supercoiled DNA. Topo II plays an important role in DNA replication and is required for condensation and segregation of chromosomes. The expression of topo II is cell cycle dependent with both protein levels and catalytic activity peaking at G2/M. Phosphorylation/dephosphorylation of topo II may be a part of regulatory checkpoints at the entry and progression of mitosis.

Citations

Dec 18, 2013·Chromosoma·Vladimir V SherstyukSuren M Zakian
Sep 11, 2014·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Kouji HirotaShunichi Takeda
Mar 23, 2007·The Biochemical Journal·Randy Y C Poon
Aug 21, 2012·Antioxidants & Redox Signaling·V Ashutosh Rao
Jun 22, 2016·The Journal of Cell Biology·Heather EdgertonDuncan J Clarke
Sep 28, 1998·Biochimica Et Biophysica Acta·A K Larsen, A Skladanowski
May 1, 2007·Molecular Cell·Yu-Xin Xu, James L Manley

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