The Roles of Embryonic Transcription Factor BRACHYURY in Tumorigenesis and Progression

Frontiers in Oncology
Ming ChenJun Shen

Abstract

Transcription factor brachyury, with a DNA-binding T-domain, regulates posterior mesoderm formation and notochord development through binding with highly conserved palindromic consensus sequence in a variety of organisms. The absence of brachyury expression in majority of adult normal tissues and exclusive tumor-specific expression provides the potential to be developed into a novel and promising diagnostic and therapeutic target in cancer. As a sensitive and specific marker in the diagnosis of chordoma, brachyury protein has been verified to involve in the process of carcinogenesis and progression of chordoma and several epithelial carcinomas in various studies, but the mechanism by which brachyury promotes tumor cells migrate, invade and metastasis still remains less clear. To this end, we attempt to summarize the literature on the upstream regulatory pathway of brachyury transcription and downstream controlling network by brachyury activation, all of which involve in both the embryonic development and tumor progression. We present the respective correlation of brachyury expression with tumor progression, distant metastasis, survival rate and prognosis in several types of tumor samples (including chordoma, lung cancer, breast...Continue Reading

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Citations

Feb 24, 2021·Stem Cells Translational Medicine·Stuart P Atkinson
Apr 10, 2021·Cell Chemical Biology·Kusal T G SamarasingheCraig M Crews
Apr 9, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mana TakiMasaki Mandai
Sep 9, 2021·Chembiochem : a European Journal of Chemical Biology·Zhenyi Hu, Craig M Crews

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Methods Mentioned

BETA
ChIP-seq
xenografts

Clinical Trials Mentioned

NCT03493945

Software Mentioned

BRACHYURY

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