The roles of endothelial nitric oxide synthase gene polymorphisms in diabetes mellitus and its associated vascular complications: a systematic review and meta-analysis

Endocrine
Jinnan DongYang Zhang

Abstract

The roles of endothelial nitric oxide synthase (eNOS) gene polymorphisms in diabetes mellitus (DM) were intensively analyzed, but the results of these studies were inconsistent. Therefore, we performed this study to better assess the relationship between eNOS genetic variations and DM. Eligible studies were searched in PubMed, Medline, Embase, and Web of Science. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess correlations between eNOS polymorphisms and DM. A total of 91 studies were finally included in our analyses. Significant associations with the susceptibility to DM were detected for the rs891512, rs1799983, rs2070744, and rs869109213 polymorphisms. As for vascular complications in DM, significant associations with the susceptibility to diabetic nephropathy were detected for the rs1799983 and rs2070744 polymorphisms. In addition, we also found that the rs1799983 polymorphism was significantly associated with the susceptibility to peripheral artery disease, whereas the rs2070744 polymorphism was significantly associated with the susceptibility to coronary artery disease in DM patients. Further subgroup analyses on the basis of type of disease and ethnicity of participants showed similar positive re...Continue Reading

References

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Citations

Dec 4, 2019·The Pharmacogenomics Journal·Elena García-MartínFélix Javier Jiménez-Jiménez
Mar 20, 2019·BMC Cardiovascular Disorders·Xia ZhangJian Zhang
Apr 10, 2019·Bioscience Reports·Cheng TanShoujun Yang
Dec 12, 2018·Journal of Cellular Biochemistry·Minjie LiHaiqing Yu
Sep 17, 2020·Revista da Associação Médica Brasileira·Aylin Hande GokceHafize Uzun
Jan 20, 2019·Experimental and Molecular Pathology·Jun WangAining Sun
Apr 1, 2020·Journal of Vascular Research·Andrzej PawlikVioletta Dziedziejko

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