The Roles of EP4 Prostanoid Receptors in Cancer Malignancy Signaling

Biological & Pharmaceutical Bulletin
Hiromichi Fujino

Abstract

The lipid mediator prostanoids consist of prostaglandins and thromboxanes, and are synthesized from arachidonic acid by the action of cyclooxygenase. There are five major prostanoids, including prostaglandin E2 (PGE2), and they are involved in a variety of biological responses such as inflammation, allergy, parturition, and tumorigenesis. These prostanoids exert their effects via activation of their cognate G protein coupled receptors, e.g., E-type prostanoid (EP) receptors for PGE2. The EP receptors are composed of four subtypes, namely EP1 to EP4. Here, breakthroughs in the last dozen years of research are introduced, with a special focus on some important findings of EP4 receptor-mediated signaling and the signaling associated with cancer development, particularly in colon cancer.

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Citations

Mar 30, 2018·International Journal of Molecular Sciences·Mousumi MajumderPeeyush K Lala
Dec 1, 2017·Scientific Reports·Takeo NakanishiIkumi Tamai
Jul 11, 2018·Frontiers in Immunology·Federico Remes LenicovAna Ceballos
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Jul 31, 2020·The Journal of Biological Chemistry·Suzu EndoHiromichi Fujino
Jun 24, 2020·BMC Veterinary Research·Margaret L MusserChad M Johannes
Dec 10, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Qiaowei FanHulun Li
Jan 14, 2020·Prostaglandins & Other Lipid Mediators·Benjamin L WoolbrightJohn A Taylor

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