The roles of ERAP1 and ERAP2 in autoimmunity and cancer immunity: New insights and perspective

Molecular Immunology
Farhad BabaieHamed Mohammadi

Abstract

Autoimmunity and cancer affect millions worldwide and both, in principal, result from dysregulated immune responses. There are many well-known molecules involved in immunological process playing as a double-edged sword, by which associating autoimmune diseases and cancer. In this regard, Endoplasmic reticulum aminopeptidases (ERAP) 1, which belongs to the M1 family of aminopeptidases, plays a central role as a "molecular ruler", proteolyzing of N-terminal of the antigenic peptides before their loading onto HLA-I molecules for antigen presentation in the Endoplasmic Reticulum (ER). Several genome-wide association studies (GWAS) highlighted the significance of ERAP1 and ERAP2 in autoimmune diseases, including Ankylosing spondylitis, Psoriasis, Bechet's disease, and Birdshot chorioretinopathy, as well as in cancers. The expression of ERAP1/2 is mostly altered in different cancers compared to normal cells, but how this affects anti-cancer immune responses and cancer growth has been little explored. Recent studies on the immunological outcomes and the catalytic functions of ERAP1 and ERAP2 have provided a better understanding of their potential pathogenetic role in autoimmunity and cancer. In this review, we summarize the role of ER...Continue Reading

Citations

Aug 23, 2020·International Journal of Molecular Sciences·Ombretta MelaiuDoriana Fruci
Dec 29, 2020·European Journal of Medicinal Chemistry·Medve LauraDeprez-Poulain Rebecca
Feb 2, 2021·Immunological Investigations·Faezeh RamezaniHamed Mohammadi
Feb 8, 2021·International Journal of Rheumatic Diseases·Mehrdad EbrazehHamed Mohammadi
Jan 23, 2021·Journal of Biochemistry·Masafumi TsujimotoAtsushi Ohnishi
Jul 17, 2021·ACS Medicinal Chemistry Letters·Safia Deddouche-GrassNicolas Basse
Sep 10, 2021·Journal of Gastrointestinal Cancer·Alireza Rezayi SoufianiAbdolreza Mehdinavaz Aghdam
Sep 20, 2021·IUBMB Life·Ramin HosseinzadehHamed Mohammadi
Nov 3, 2021·Investigative Ophthalmology & Visual Science·Sahar GelfmanUNKNOWN Regeneron Genetics Center

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.