Abstract
This systematic review and meta-analysis aimed to better elucidate the roles of genetic factors in Kawasaki disease (KD), and determine the potential genetic biomarkers of KD. The systematic literature search of PubMed, Medline, Embase, Web of Science and CNKI identified 164 eligible studies. The qualitative synthesis revealed that 62 genes may be correlated with the susceptibility to KD, and 47 genes may be associated with the incidence of coronary artery lesions (CALs) in KD. A total of 53 polymorphisms in 34 genes were investigated in further quantitative synthesis. Of these, 23 gene polymorphisms were found to be significantly correlated with KD susceptibility, and 10 gene polymorphisms were found to be significantly associated with the incidence of CALs in KD. In conclusion, our findings indicate that gene polymorphisms of ACE, BLK, CASP3, CD40, FCGR2A, FGβ, HLA-E, IL1A, IL6, ITPKC, LTA, MPO, PD1, SMAD3, CCL17 and TNF may affect KD susceptibility. Besides, genetic variations in BTNL2, CASP3, FCGR2A, FGF23, FGβ, GRIN3A, HLA-E, IL10, ITPKC and TGFBR2 may serve as biomarkers of CALs in KD.
References
Oct 18, 2005·Trends in Cardiovascular Medicine·Marcel Levi, Tom van der Poll
Oct 21, 2006·Archives of Oral Biology·André Luiz Sena GuimarãesRicardo Santiago Gomez
Jun 19, 2007·Cardiology in Review·Gary M SatouMichael H Gewitz
Dec 18, 2007·Nature Genetics·Yoshihiro OnouchiAkira Hata
Jan 8, 2008·Journal of Pediatric Hematology/oncology·Selma UnalAytemiz Gurgey
Aug 30, 2008·Journal of Leukocyte Biology·Marcela ClaudinoGustavo P Garlet
Jan 31, 2009·Arthritis and Rheumatism·Y-J LinF-J Tsai
Jun 11, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ryo OtaTomoki Hashimoto
Jul 9, 2009·Journal of the American College of Cardiology·Paul M HassounMarc Humbert
Jul 23, 2009·Annals of Internal Medicine·David MoherUNKNOWN PRISMA Group
Sep 1, 2009·Yonsei Medical Journal·Hyun Hee LeeDong Soo Kim
Apr 29, 2010·Human Molecular Genetics·Yoshihiro OnouchiToshihiro Tanaka
Jul 24, 2010·European Journal of Epidemiology·Andreas Stang
Dec 24, 2010·Clinical and Experimental Immunology·L GiordaniM Viora
Nov 15, 2011·Nature Genetics·Chiea Chuen KhorUNKNOWN Blue Mountains Eye Study
Mar 27, 2012·Nature Genetics·Yoshihiro OnouchiUNKNOWN US Kawasaki Disease Genetics Consortium
Mar 27, 2012·Journal of Epidemiology·Yosikazu NakamuraHiroshi Yanagawa
May 15, 2012·Antioxidants & Redox Signaling·Elisabetta StrafaceDonatella Pietraforte
Jun 23, 2012·PloS One·Jan Marc OrensteinAnne H Rowley
Jun 26, 2012·Pediatrics International : Official Journal of the Japan Pediatric Society·Eeva SaloJane C Burns
Jul 17, 2012·Cytokine·Ana Paula Ribeiro BraosiPaula Cristina Trevilatto
Nov 29, 2012·Clinical and Experimental Nephrology·Kei TakahashiTsutomu Saji
Jan 25, 2013·Pediatric Research·Rebecca ReindelAnne H Rowley
Feb 8, 2013·Biomaterials·Yasmine AssalEiry Kobatake
Jun 29, 2013·Free Radical Biology & Medicine·Carla S CeronJose E Tanus-Santos
Sep 26, 2013·The Pediatric Infectious Disease Journal·Gi Beom KimSohee Park
Nov 20, 2013·Current Opinion in Rheumatology·Kei TakahashiYuki Yokouchi
Apr 20, 2014·Current Rheumatology Reports·Victoria R DimitriadesAbraham Gedalia
Jul 22, 2014·Nature Immunology·Andrew PinceticJeffrey V Ravetch
Sep 23, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·UNKNOWN JCS Joint Working Group
Dec 3, 2014·Biochemical and Biophysical Research Communications·Fu GaoWei Li
Jan 15, 2015·Allergy·M M-H GuoH-C Kuo
Jan 22, 2015·Circulation Research·Tai-Ming KoYuan-Tsong Chen
Feb 1, 2015·Journal of the Chinese Medical Association : JCMA·Ming-Chih LinYun-Ching Fu
Apr 18, 2015·Autoimmunity Reviews·Antonio GrecoMarco de Vincentiis
Apr 25, 2015·Nature Reviews. Rheumatology·Stanford T Shulman, Anne H Rowley
Sep 8, 2015·Redox Biology·Danielle A GuimarãesJose E Tanus-Santos
Oct 27, 2015·Immunological Reviews·Andrew Getahun, John C Cambier
Dec 1, 2015·Korean Circulation Journal·Sang Bum LeeYoung Hwan Lee
Dec 4, 2015·Yonsei Medical Journal·Kyu Yeun Kim, Dong Soo Kim
Apr 9, 2016·Journal of the American College of Cardiology·Jane W NewburgerJane C Burns
Nov 20, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kazuyuki TsujinoDean Sheppard
Jan 13, 2017·Pediatric Annals·Stanford T Shulman
Citations
Feb 1, 2019·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Jun 7, 2019·The Journal of Clinical Investigation·Chie MiyabeAndrew D Luster
Oct 11, 2019·Current Opinion in Rheumatology·Francesca TirelliRolando Cimaz
Jan 30, 2020·Circulation·Salim S ViraniUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Aug 10, 2020·The FEBS Journal·Donald Y M Leung, Patrick M Schlievert
Sep 29, 2020·Frontiers in Pediatrics·Danfeng ZhangJie Tian
Jul 17, 2020·Frontiers in Cardiovascular Medicine·Mark Daniel Hicar
Feb 2, 2019·BMC Pediatrics·Meng XuSirui Yang
Mar 23, 2020·Clinical Reviews in Allergy & Immunology·Rajni KumrahSurjit Singh
Jan 28, 2021·Circulation·Salim S ViraniUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
May 27, 2020·The Journal of Pediatrics·Ryusuke AeYosikazu Nakamura
Apr 7, 2021·JAMA Network Open·Takuya HaraToshiro Hara
Jun 1, 2021·Frontiers in Pediatrics·Hsiao-Wen ChuYa-Chi Hsu