The Roles of Glutamine in the Intestine and Its Implication in Intestinal Diseases

International Journal of Molecular Sciences
Min-Hyun Kim, Hyeyoung Kim

Abstract

Glutamine, the most abundant free amino acid in the human body, is a major substrate utilized by intestinal cells. The roles of glutamine in intestinal physiology and management of multiple intestinal diseases have been reported. In gut physiology, glutamine promotes enterocyte proliferation, regulates tight junction proteins, suppresses pro-inflammatory signaling pathways, and protects cells against apoptosis and cellular stresses during normal and pathologic conditions. As glutamine stores are depleted during severe metabolic stress including trauma, sepsis, and inflammatory bowel diseases, glutamine supplementation has been examined in patients to improve their clinical outcomes. In this review, we discuss the physiological roles of glutamine for intestinal health and its underlying mechanisms. In addition, we discuss the current evidence for the efficacy of glutamine supplementation in intestinal diseases.

References

Aug 1, 1990·Nutrition Reviews·J M Lacey, D W Wilmore
Feb 1, 1990·Journal of Animal Science·J F Patience
Oct 15, 1990·Biochemical and Biophysical Research Communications·T A SwierkoszJ R Vane
Jan 1, 1990·The Journal of Surgical Research·W W SoubaE M Copeland
Nov 1, 1995·JPEN. Journal of Parenteral and Enteral Nutrition·A L BuchmanS R Vijayaroghavan
Oct 1, 1996·The Journal of Pathology·M IwamotoP K Nakane
Jun 16, 1997·The Journal of Cell Biology·A SakakibaraS Tsukita
Apr 7, 1998·JPEN. Journal of Parenteral and Enteral Nutrition·R McCauleyJ Hall
Apr 29, 1998·Annual Review of Physiology·L L Mitic, J M Anderson
Aug 4, 1998·The Journal of Nutrition·G Wu
Nov 20, 1998·The Journal of Clinical Investigation·J M KimM F Kagnoff
Jan 15, 1999·JPEN. Journal of Parenteral and Enteral Nutrition·E Den HondP Rutgeerts
Apr 15, 1999·European Journal of Clinical Investigation·A G Hall
Apr 17, 1999·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·A P HoudijkP A van Leeuwen
Jun 5, 1999·Molecular Genetics and Metabolism·M I Amores-Sánchez, M A Medina
Jan 12, 2000·Journal of Pediatric Gastroenterology and Nutrition·A K AkobengA G Thomas
Jan 25, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·A J Watson, D M Pritchard
Mar 29, 2000·Journal of Gastroenterology and Hepatology·A RamachandranK A Balasubramanian
Sep 1, 2000·The American Journal of Medicine·P Kubes, D M McCafferty
Sep 6, 2000·The British Journal of Surgery·J MacFie
Mar 15, 2001·Current Opinion in Cell Biology·J N Ihle
Mar 31, 2001·Intensive Care Medicine·H M Oudemans-van StraatenD F Zandstra
Aug 2, 2001·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·J S ScolapioO L Burnett
Aug 21, 2001·Biochemical and Biophysical Research Communications·C GarridoG Kroemer
Aug 23, 2001·International Immunopharmacology·J W Coleman
Sep 5, 2001·The Journal of Nutrition·A M KarinchW W Souba
Feb 22, 2002·Biochemical and Biophysical Research Communications·Vivek MalhotraHector R Wong
Mar 8, 2002·Nutrition·Erich RothAndreas Spittler
Mar 8, 2002·Nutrition·Paul E Wischmeyer
Mar 22, 2002·The International Journal of Biochemistry & Cell Biology·José M MatésJavier Márquez
Sep 28, 2002·Critical Care Medicine·Frantisek NovakXiangyao Su
Sep 28, 2002·Critical Care Medicine·Christiane GoetersHans-Georg Bone
Dec 12, 2002·Progress in Biophysics and Molecular Biology·L González-MariscalB E Jaramillo
Jul 4, 2003·The Journal of Nutrition·Vincent G DeMarcoJosef Neu

❮ Previous
Next ❯

Citations

Aug 9, 2019·Molecular Nutrition & Food Research·Florian RohmBritta Spanier
Feb 8, 2020·Immunity, Inflammation and Disease·Joris H J van SadelhoffJohan Garssen
Oct 27, 2018·Nutrients·Vinicius CruzatPhilip Newsholme
Jan 11, 2020·Frontiers in Physiology·Iain T ParsonsDavid R Woods
Jul 14, 2018·Infection·Stelios F AssimakopoulosCharalambos A Gogos
Apr 24, 2018·BioMed Research International·Fang HeYuanyi Peng
May 7, 2019·Frontiers in Endocrinology·Joris H J van SadelhoffAletta D Kraneveld
Nov 7, 2019·Oxidative Medicine and Cellular Longevity·B PoljsakA Starc
Aug 15, 2019·Journal of Medical Internet Research·Martín Pérez-PérezAnália Lourenço
Dec 22, 2019·Nutrients·Sabrina Donati ZeppaVilberto Stocchi
Apr 21, 2020·World Journal of Gastroenterology : WJG·Magdy El-Salhy
Jul 14, 2020·World Journal of Gastroenterology : WJG·Vanessa A ArecoMaría E Peralta López
Mar 31, 2018·Frontiers in Immunology·Cristina DumitruKevin J Maloy
Oct 28, 2019·International Journal of Molecular Sciences·Simone PernaMariangela Rondanelli
Jul 1, 2020·Probiotics and Antimicrobial Proteins·Rajesh VenkataramanStephy Stephen
Jan 8, 2020·International Journal of Molecular Sciences·Louise InjarabianBenoit S Marteyn
Oct 31, 2020·Advances in Nutrition·Mark F McCarty, Aaron Lerner
Jan 5, 2021·Pediatric Surgery International·Michael E Höllwarth, Valeria Solari
Jan 30, 2021·Inflammatory Bowel Diseases·Maria Laura SantoruLuigi Atzori
Nov 12, 2020·Journal of Crohn's & Colitis·Kate GallagherHorace R T Williams
Dec 31, 2020·International Journal of Molecular Sciences·Marc Micó-CarneroCarmen Peralta
Mar 23, 2021·Clinical Nutrition ESPEN·Juliana Soares SeveroMoisés Tolentino
Sep 6, 2019·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Zahra Vahdat ShariatpanahiAhmad-Reza Baghestani
May 1, 2021·International Journal of Molecular Sciences·Kawthar BoumessidEmmanuel Mas

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear translocation

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

© 2022 Meta ULC. All rights reserved