The Roles of miRNAs in Medulloblastoma: A Systematic Review

Journal of Cancer Prevention
Behrouz MollashahiAbolfazl Movafagh

Abstract

Medulloblastoma is considered one of the most threatening malignant brain tumors with an extremely high mortality rate in children. In the medulloblastoma, there are several genes and mutations found to work in an unregulated manner that works together to push the cells into a cancerous state. With the discovery of non-coding RNAs such as microRNAs (miRNAs), it has been shown that a different layer of gene regulations may be disrupted which would cause cancer. This fact led scientists to put their focus on the role of miRNAs in cancer. A mature miRNA contains a seed sequence which gives the miRNA to identify and attach to the interest mRNA; this attachment may lead degradation of mRNA or suppress of translation of the mRNA. The expression of miRNAs in medulloblastoma shows that some of these non-coding RNAs are overexpressed (OncomiRs) which help cells to proliferate and keep their stemness features. On the other hand, there are other forms of these miRNAs which normally inhibit cell proliferation and promote cell differentiation (tumor suppressor). These are down-regulated during cancer progression. In this systematic review, we attempted to gather several important studies on miRNAs' role in medulloblastoma tumors and the imp...Continue Reading

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Citations

Jan 11, 2020·Cancer Metastasis Reviews·Hisham F BahmadWassim Abou-Kheir
Aug 21, 2020·Journal of Neuro-oncology·Amanda R HaltomSoumen Khatua
Nov 28, 2020·Current Treatment Options in Oncology·Hussein HammoudSanaa Nabha
Jun 3, 2021·International Journal of Molecular Sciences·Agata StrejczekAnna-Maria Barciszewska

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