The Roles of Mitogen-Activated Protein Kinase Pathways in TGF-β-Induced Epithelial-Mesenchymal Transition.

Journal of Signal Transduction
Ting GuiYasuteru Muragaki

Abstract

The mitogen-activated protein kinase (MAPK) pathway allows cells to interpret external signals and respond appropriately, especially during the epithelial-mesenchymal transition (EMT). EMT is an important process during embryonic development, fibrosis, and tumor progression in which epithelial cells acquire mesenchymal, fibroblast-like properties and show reduced intercellular adhesion and increased motility. TGF-β signaling is the first pathway to be described as an inducer of EMT, and its relationship with the Smad family is already well characterized. Studies of four members of the MAPK family in different biological systems have shown that the MAPK and TGF-β signaling pathways interact with each other and have a synergistic effect on the secretion of additional growth factors and cytokines that in turn promote EMT. In this paper, we present background on the regulation and function of MAPKs and their cascades, highlight the mechanisms of MAPK crosstalk with TGF-β signaling, and discuss the roles of MAPKs in EMT.

References

Dec 10, 1991·Biochimica Et Biophysica Acta·P Angel, M Karin
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·T Hai, T Curran
May 26, 1995·The Journal of Biological Chemistry·G ZhouJ E Dixon
Apr 1, 1996·Current Opinion in Cell Biology·R Treisman
Apr 1, 1997·Current Opinion in Cell Biology·M KarinE Zandi
Dec 12, 1997·Biochimica Et Biophysica Acta·R Derynck, X H Feng
Apr 30, 1998·Current Opinion in Cell Biology·Y T Ip, R J Davis
Dec 29, 1998·Cell·R DerynckX H Feng
Mar 19, 1999·Molecular and Cellular Biology·H J Schaeffer, M J Weber
Aug 14, 1999·The Journal of Biological Chemistry·J C HedgesW T Gerthoffer
Dec 22, 1999·The Journal of Biological Chemistry·M E EngelH L Moses
Jun 1, 2000·Gene·C M Zimmerman, R W Padgett
Jul 6, 2000·Advances in Immunology·K MiyazonoC H Heldin
Jul 25, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B R HuD J Park
Sep 7, 2000·Journal of the National Cancer Institute·M P de CaesteckerA B Roberts
Nov 14, 2000·The Journal of Biological Chemistry·W SunG L Johnson
Dec 2, 2000·Nature Structural Biology·T Smith
Feb 7, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y ZhangR Derynck
Mar 10, 2001·Leukemia·S BaileyC P Redfern
Mar 10, 2001·Nature·L Chang, M Karin
Mar 17, 2001·Nature Reviews. Genetics·T Casci
Mar 17, 2001·Nature Reviews. Molecular Cell Biology·J Massagué
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·J ZavadilE P Bottinger
Oct 5, 2001·Nature Genetics·R DerynckA Balmain
Jan 16, 2002·Current Opinion in Genetics & Development·Lalage M Wakefield, Anita B Roberts
Feb 2, 2002·Nature Reviews. Molecular Cell Biology·Catherine A Hazzalin, Louis C Mahadevan
Feb 28, 2002·Science's STKE : Signal Transduction Knowledge Environment·D C Merz, J G Culotti
Feb 28, 2002·Science's STKE : Signal Transduction Knowledge Environment·T JunT M Roberts
May 4, 2002·Nature Cell Biology·Eitan Shaulian, Michael Karin
May 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Andy WongArnold Li
Oct 3, 2002·Cellular Signalling·Marion Lutz, Petra Knaus

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Citations

Jul 10, 2014·Expert Opinion on Therapeutic Targets·Filippa PetterssonWilson H Miller
Feb 6, 2016·Journal of Clinical Medicine·Nisha DurandPeter Storz
Mar 5, 2016·Stem Cells International·Raffaele StrippoliMarco Tripodi
Dec 9, 2015·Cellular and Molecular Neurobiology·Haitao TangPeng Liang
Jun 15, 2014·Experimental Cell Research·Min Jin LimJie-Young Song
May 4, 2016·Cell and Tissue Banking·Galyna OstrovskaNataliia Savytska
Jul 12, 2016·European Journal of Cell Biology·Christine-Maria Horejs
Jan 10, 2019·Animal : an International Journal of Animal Bioscience·Y F ZhuX J Yang
Dec 14, 2018·The Journal of Biological Chemistry·Jin Won YangShelly C Lu
Jan 24, 2019·Proteomics·Shu Wen WenAndreas Möller
Jul 24, 2013·International Journal of Oncology·Qian XuYuhong Li
Jul 15, 2015·The EMBO Journal·Sanjeeb Kumar SahuVijay K Tiwari
Jul 28, 2019·The FEBS Journal·Liang GuMandeep Kaur
Jun 5, 2016·The Journal of Biological Chemistry·Kumarkrishna RaychaudhuriSorab N Dalal
Dec 5, 2019·Mutagenesis·Kerstin HuebnerRegine Schneider-Stock
Apr 2, 2020·Expert Opinion on Therapeutic Patents·Vanessa HallerStefan A Laufer
Aug 26, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tianfang HuangTodd D Camenisch
Feb 6, 2020·Cells·Sergio LiarteFrancisco J Nicolás
Oct 22, 2019·Therapeutic Advances in Medical Oncology·Yi Jer TanChern Ein Oon
Jul 5, 2018·Veterinary Research·Carly A HamiltonNeil A Mabbott
Sep 26, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hui WangLiang Zhao
Nov 13, 2020·Frontiers in Immunology·Vanessa Figliuolo da PazPawel R Kiela
Feb 20, 2021·G3 : Genes - Genomes - Genetics·Corinna Jie Hui GohPrakash Arumugam

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Methods Mentioned

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nuclear translocation
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