The roles of non-coding RNAs in cardiac regenerative medicine

Non-coding RNA Research
Oi Kuan ChoongPatrick C H Hsieh

Abstract

The emergence of non-coding RNAs (ncRNAs) has challenged the central dogma of molecular biology that dictates that the decryption of genetic information starts from transcription of DNA to RNA, with subsequent translation into a protein. Large numbers of ncRNAs with biological significance have now been identified, suggesting that ncRNAs are important in their own right and their roles extend far beyond what was originally envisaged. ncRNAs do not only regulate gene expression, but are also involved in chromatin architecture and structural conformation. Several studies have pointed out that ncRNAs participate in heart disease; however, the functions of ncRNAs still remain unclear. ncRNAs are involved in cellular fate, differentiation, proliferation and tissue regeneration, hinting at their potential therapeutic applications. Here, we review the current understanding of both the biological functions and molecular mechanisms of ncRNAs in heart disease and describe some of the ncRNAs that have potential heart regeneration effects.

Citations

Dec 14, 2018·Cells·Miruna Mihaela MicheuMaria Dorobantu
Sep 20, 2018·Non-coding RNA·Zesergio MeloRaquel Echavarria
Jan 18, 2019·Journal of Cardiovascular Development and Disease·Adriana M Rodriguez, Viravuth P Yin
Apr 24, 2018·Annals of the New York Academy of Sciences·Harpreet KaurPallab Bhattacharya
Mar 20, 2019·Biochimica Et Biophysica Acta. Molecular Cell Research·Anne-Charlotte Bon-MathierNathalie Rosenblatt-Velin
Apr 4, 2021·Non-coding RNA·Maryam Kay, Bahram M Soltani
Apr 13, 2021·Frontiers in Physiology·Ting Yuan, Jaya Krishnan
Aug 31, 2021·Cardiovascular Research·Maryam KayThierry Pedrazzini
Jan 19, 2022·Clinical and Translational Medicine·Serena Wooten, Keriayn N Smith

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Methods Mentioned

BETA
HITS-CLIP
transfection
antisense oligonucleotides
chemical modification

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