The roles of physiological and subjective stress in the effectiveness of a placebo on experimentally induced pain

Psychosomatic Medicine
Per M Aslaksen, Magne Arve Flaten

Abstract

To examine whether reduction of negative emotions and associated autonomic activity could explain placebo analgesia, and to test the effect of experimenter gender on the placebo analgesic response. Sixty-three (n = 32 females) students participated in a within-subjects design where subjects were tested on two separate days, one day for the experimental condition (placebo) and one day for the natural history condition. In the experimental condition, the participants received capsules containing lactose with information that the capsules were a high dose of a potent painkiller. In the natural history condition, the procedures were identical except that the placebo capsules were not administrated. The experimenters were blinded to the fact that all participants received placebo. Pain was induced by a thermode holding +46 degrees C with duration of 240 seconds to the forearm. Electrocardiogram was measured to obtain data for analysis of heart rate variability. Subjective measurements consisted of pain intensity, pain unpleasantness, stress, arousal, and mood. The results showed a placebo effect on pain intensity and a concomitant reduction in subjective stress and cardiac activity. Stepwise regressions revealed that reduced subject...Continue Reading

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Citations

May 18, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Magne Arve FlatenEspen Bjørkedal
Nov 16, 2012·PloS One·Katja WeimerSibylle Klosterhalfen
Jan 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tor D WagerJames K Rilling
Nov 11, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Karin MeissnerMagne Arve Flaten
Oct 11, 2012·Journal of Pain Research·Espen Bjørkedal, Magne Arve Flaten
Dec 25, 2015·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·M A FlatenT D Blumenthal
Mar 24, 2010·Journal of Psychosomatic Research·Peter Solvoll LybyMagne Arve Flaten
Aug 8, 2013·European Journal of Pain : EJP·J KoenigJ F Thayer
Nov 26, 2009·Scandinavian Journal of Psychology·Magne Arve Flaten
Apr 2, 2015·Biological Psychology·Sonja ÜbelAnne Schienle
Mar 27, 2012·Medical Hypotheses·Rainer Schneider, Julius Kuhl
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Aug 31, 2011·Pain·Peter Solvoll LybyMagne Arve Flaten
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Oct 29, 2020·Psychosomatic Medicine·Eleonora Maria CameroneElisa Carlino
Feb 24, 2021·European Journal of Pain : EJP·Eleonora Maria CameroneMarco Testa
Jun 25, 2021·Frontiers in Psychology·Sara Magelssen VambheimMagne Arve Flaten
Jul 31, 2021·PloS One·Anders Deichmann SpringborgMads Utke Werner
Aug 31, 2021·European Eating Disorders Review : the Journal of the Eating Disorders Association·Gemma GordonIain Campbell

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