PMID: 9557646Apr 29, 1998Paper

The roles of Pol and Env in the assembly pathway of human foamy virus

Journal of Virology
D N Baldwin, Maxine L Linial

Abstract

Human foamy virus (HFV) is the prototype of the Spumavirus genus of retroviruses. These viruses have a genomic organization close to that of other complex retroviruses but have similarities to hepadnaviruses such as human hepatitis B virus (HBV). Both HFV and HBV express their Pol protein independently of their structural proteins. Retroviruses and hepadnaviruses differ in their requirements for particle assembly and genome packaging. Assembly of retroviral particles containing RNA genomes requires only the Gag structural protein. The Pol protein is not required for capsid assembly, and the Env surface glycoprotein is not required for release of virions from the cell. In contrast, assembly of extracellular HBV particles containing DNA requires core structural protein and polymerase (P protein) for assembly of nucleocapsids and requires surface glycoproteins for release from the cell. We investigated the requirements for synthesis of extracellular HFV particles by constructing mutants with either the pol or env gene deleted. We found that the Pol protein is dispensable for production of extracellular particles containing viral nucleic acid. In the absence of Env, intracellular particles are synthesized but few or no extracellula...Continue Reading

Citations

Apr 29, 2005·Journal of Virology·Gillian S PattonMyra O McClure
Mar 9, 2007·Journal of Virology·Jacqueline Roy, Maxine L Linial
Jul 5, 2005·Journal of Virology·Jacqueline Lehmann-CheAli Saïb
Aug 8, 2008·Journal of Virology·Annett StangeDirk Lindemann
Oct 14, 2011·Viruses·Dirk Lindemann, Axel Rethwilm
Jan 29, 2003·Journal of Virology·Kit L ShawPaul A Goepfert
Jun 14, 2003·Journal of Virology·Evelina Shikova-LekovaAxel Rethwilm
Sep 12, 2009·Expert Opinion on Biological Therapy·Grant D Trobridge
Apr 12, 2013·Viruses·Sylvia HütterDirk Lindemann
Dec 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Maria ZhadinaPaul D Bieniasz
Nov 25, 2003·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·J WeikelU Truyen
Mar 23, 2013·Viruses·Eun-Gyung LeeMaxine L Linial
Mar 28, 2008·Journal of Virology·Melvyn W YapJonathan P Stoye
Nov 8, 2013·Journal of Virology·Carolyn R StenbakMaxine L Linial
Sep 3, 2016·Viruses·Martin V Hamann, Dirk Lindemann
Nov 25, 2003·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·P BastoneM Löchelt
Mar 27, 2001·Journal of Virology·D CainM O McClure
Aug 17, 2004·Journal of Virology·Carolyn R Stenbak, Maxine L Linial
Jan 9, 2001·Clinical Microbiology Reviews·C D Meiering, M L Linial

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