The roles of poly(ADP-ribose)-metabolizing enzymes in alkylation-induced cell death

Cellular and Molecular Life Sciences : CMLS
O CohauszFelix R Althaus

Abstract

Poly(ADP-ribose) (PAR) has been identified as a DNA damage-inducible cell death signal upstream of apoptosis-inducing factor (AIF). PAR causes the translocation of AIF from mitochondria to the nucleus and triggers cell death. In living cells, PAR molecules are subject to dynamic changes pending on internal and external stress factors. Using RNA interference (RNAi), we determined the roles of poly(ADP-ribose) polymerases-1 and -2 (PARP-1, PARP-2) and poly(ADP-ribose) glycohydrolase (PARG), the key enzymes configuring PAR molecules, in cell death induced by an alkylating agent. We found that PARP-1, but not PARP-2 and PARG, contributed to alkylation-induced cell death. Likewise, AIF translocation was only affected by PARP-1. PARP-1 seems to play a major role configuring PAR as a death signal involving AIF translocation regardless of the death pathway involved.

Citations

Sep 30, 2010·Cellular and Molecular Life Sciences : CMLS·C BlennFelix R Althaus
Jul 1, 2008·Cell Biology and Toxicology·Odile Cohausz, Felix R Althaus
May 5, 2009·The Journal of Biological Chemistry·Laura FormentiniAlberto Chiarugi
Oct 7, 2008·Nucleic Acids Research·Sascha BenekeAlexander Bürkle
Jul 3, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Katalin ErdélyiLászló Virág
Jul 4, 2012·Molecular and Cellular Biology·Philippe WyrschFelix R Althaus
Oct 11, 2012·Oxidative Medicine and Cellular Longevity·Aswin Mangerich, Alexander Bürkle
Jan 14, 2010·Molecular Cancer Research : MCR·Jiang-bo TangRobert W Sobol
Feb 7, 2013·Cell Communication and Signaling : CCS·Philippe WyrschFelix R Althaus
Nov 26, 2015·Free Radical Biology & Medicine·Ryo YonezawaShunichi Shimizu
Sep 20, 2015·The International Journal of Biochemistry & Cell Biology·Shunichi ShimizuTakahiro Toda
Dec 28, 2010·International Journal for Parasitology·Salomé C Vilchez LarreaSilvia H Fernández Villamil
Mar 2, 2011·The American Journal of Pathology·Xueqing Ba, Nisha Jain Garg
Jan 1, 2012·Genes·Christian BlennFelix R Althaus
Feb 24, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Christian BlennFelix R Althaus
Nov 7, 2013·The Journal of Biological Chemistry·Daniela BuonvicinoAlberto Chiarugi
Apr 18, 2009·Molecular Cancer Therapeutics·James B Kirkland
Apr 4, 2021·International Journal of Molecular Sciences·Abhishek Chandra, Jyotika Rajawat

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Apoptosis : an International Journal on Programmed Cell Death
Chantal EthierG G Poirier
Nature Reviews. Molecular Cell Biology
Valérie SchreiberGilbert de Murcia
Proceedings of the National Academy of Sciences of the United States of America
S A AndrabiT M Dawson
© 2021 Meta ULC. All rights reserved