The roles of Reactive Oxygen Species and Antioxidants in Cryopreservation

Bioscience Reports
Jia Soon LenShi-Xiong Tan

Abstract

Cryopreservation has facilitated advancement of biological research by allowing the storage of cells over prolonged periods of time. While cryopreservation at extremely low temperatures would render cells metabolically inactive, cells suffer insults during the freezing and thawing process. Amongst such insults, the generation of supra-physiological levels of reactive oxygen species (ROS) could impair cellular functions and survival. Antioxidants are potential additives that were reported to partially or completely reverse freeze-thaw stress-associated impairments. This review aims to discuss the potential sources of cryopreservation-induced ROS and the effectiveness of antioxidant administration when used individually or in combination.

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Citations

Apr 29, 2020·Zygote : the Biology of Gametes and Early Embryos·M JamilR Cadi
Jan 6, 2021·Antioxidants·Francisca FélixElsa Cabrita
Jan 28, 2021·Animals : an Open Access Journal From MDPI·Marta F RiescoLuis Anel
Dec 9, 2020·Animals : an Open Access Journal From MDPI·Islam M SaadeldinSeok Hee Lee
Jan 9, 2021·Research in Veterinary Science·Yentel Mateo-OteroElisa Giaretta
Feb 25, 2021·Biopreservation and Biobanking·Caifeng WuDefu Zhang
Nov 28, 2020·Trends in Endocrinology and Metabolism : TEM·Sharon Baumel-AlterzonDonald K Scott
May 3, 2021·Journal of Pharmaceutical Sciences·Ute RockingerGerhard Winter
May 9, 2021·Cryobiology·José Carlos Ferreira-SilvaMarcos Antonio Lemos Oliveira
May 21, 2021·In Vitro Cellular & Developmental Biology. Animal·Young-Bum SonWoo Suk Hwang
Jul 3, 2021·Journal of Clinical Medicine·Kaan Aydos, Oya Sena Aydos
Nov 4, 2021·Scientific Reports·Aline Q RodriguesFernanda Paulini
Nov 10, 2021·Frontiers in Molecular Biosciences·Sarah A Overall, Alexander B Barnes

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Methods Mentioned

BETA
protein folding
MDA

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