The roles of TNF-alpha and the soluble TNF receptor I on sleep architecture in OSA.

Sleep & Breathing = Schlaf & Atmung
Herbert J YueJoel E Dimsdale

Abstract

Patients with obstructive sleep apnea (OSA) have been described to have increased levels of inflammatory cytokines (particularly TNF-alpha) and have severely disturbed sleep architecture. Serum inflammatory markers, even in normal individuals, have been associated with abnormal sleep architecture. Not much is known about the role the TNF receptor plays in the inflammation of OSA nor if it is associated with changes in sleep architecture or arousals during the night. We hypothesized that the TNF receptor might play an important role in the inflammation as well as sleep architecture changes in patients with OSA. Thirty-six patients with diagnosed (AHI > 15) but untreated OSA were enrolled in this study. Baseline polysomnograms as well as TNF-alpha and soluble TNF receptor I (sTNF-RI) serum levels were obtained on all patients. We evaluated the association between serum levels of TNF-alpha and sTNF-RI with various polysomongraphic characteristics, including sleep stages and EEG arousals. sTNF-RI levels were significantly correlated with snore arousals (r value 0.449, p value 0.009), spontaneous movement arousals (r value 0.378, p value 0.025), and periodic limb movement arousals (r value 0.460, p value 0.008). No statistically sig...Continue Reading

References

Sep 1, 1992·The American Review of Respiratory Disease·P E ParsonsG S Worthen
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M BrockhausH Loetscher
Oct 1, 1995·The Journal of Clinical Investigation·V K SomersF M Abboud
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·D F DarkoM M Mitler
Aug 1, 1996·The Laryngoscope·M SekosanI Rubinstein
Apr 1, 1997·American Journal of Respiratory and Critical Care Medicine·J F PittetM A Matthay
May 1, 1997·The Journal of Clinical Endocrinology and Metabolism·A N VgontzasG P Chrousos
Mar 17, 2000·The Journal of Clinical Endocrinology and Metabolism·A N VgontzasG P Chrousos
Jan 10, 2001·The Journal of Allergy and Clinical Immunology·W T ShearerD F Dinges
Jun 26, 2001·Psychiatry and Clinical Neurosciences·T HoriUNKNOWN Sleep Computing Committee of the Japanese Society of Sleep Research Society
Nov 25, 2003·Journal of Sleep Research·Andrea AlbertiVirgilio Gallai
Apr 29, 2004·JAMA : the Journal of the American Medical Association·Terry YoungPaul E Peppard
Nov 2, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Polly E ParsonsUNKNOWN National Heart, Lung, Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network
Dec 2, 2004·The Tohoku Journal of Experimental Medicine·Takeshi KataokaKatsuhisa Ikeda
Dec 13, 2005·The Journal of Allergy and Clinical Immunology·Celine BergeronQutayba Hamid
Dec 7, 2006·Respiration; International Review of Thoracic Diseases·Ahmet UrsavaşR Oktay Gözü
Feb 7, 2007·Sleep & Breathing = Schlaf & Atmung·Mónica de la Peña BravoDavid Gozal
Jun 22, 2007·Sleep·Paul J MillsJoel E Dimsdale

❮ Previous
Next ❯

Citations

Feb 8, 2011·Obesity Surgery·Maria PallayovaAlan R Schwartz
Oct 23, 2012·Clinical and Experimental Pharmacology & Physiology·Joi J Thomas, Jun Ren
Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·Javier A JoMichael C K Khoo
Aug 3, 2002·American Journal of Respiratory and Critical Care Medicine·Maria R BonsignoreGiovanni Bonsignore
Jul 7, 2010·Journal of Occupational Medicine and Toxicology·Anke van MarkBarbara Kalsdorf
Jan 3, 2012·International Journal of Clinical Rheumatology·Mary MargarettenEdward Yelin
Jul 25, 2012·Annals of the New York Academy of Sciences·Beatriz Gómez-GonzálezJavier Velázquez-Moctezuma
Feb 7, 2018·Journal of Stroke·Dae Lim KooChang-Ho Yun
Apr 26, 2014·American Journal of Clinical Oncology·Jessica Zhou, Shruti Jolly
Jul 30, 2015·International Journal of Dermatology·Camila HirotsuMonica L Andersen
Jan 30, 2021·Journal of Geriatric Psychiatry and Neurology·Regina Eun Young KimChol Shin
Feb 12, 2021·Brain, Behavior, and Immunity·Cheryl Dykstra-AielloJames M Krueger

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
enzyme-linked immunosorbent assay

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.