The roles of TNFAIP2 in cancers and infectious diseases

Journal of Cellular and Molecular Medicine
Lin JiaCeshi Chen

Abstract

TNFα-induced protein 2 (TNFAIP2) is a primary response gene of TNFα. TNFAIP2 is highly expressed in immune cells and the urinary bladder. The expression of TNFAIP2 is regulated by multiple transcription factors and signalling pathways, including NF-κB, KLF5 and retinoic acid. Physiologically, TNFAIP2 appears to be a multiple functional mediator not only for inflammation, angiogenesis and tunneling nanotube (TNT) formation but also as a regulator of cell proliferation and migration. The expression of TNFAIP2 is frequently abnormal in human cancers and in infectious diseases. Due to its significant functions in cell proliferation, angiogenesis, migration and invasion, TNFAIP2 could be a potential diagnostic biomarker and therapeutic target for cancer.

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Citations

May 28, 2020·DNA and Cell Biology·Jianing LiYao Yu
Nov 10, 2018·Cell Communication and Signaling : CCS·Eshna JashSeema Sehrawat
Aug 9, 2019·Cellular and Molecular Life Sciences : CMLS·Anica ScholzTobias Schmid
Sep 30, 2020·The Journal of Physiology·Thomas TaetzschGregorio Valdez
Mar 17, 2021·Journal of the American Society of Nephrology : JASN·Federica BaruttaGabriella Gruden
Apr 4, 2021·Cancer Science·Yao Luo, Ceshi Chen
May 8, 2021·Human Molecular Genetics·Marta R MoksnesTorbjørn Omland

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Methods Mentioned

BETA
GTPase
ChIP
biopsy
xenograft
GTPases
transgenic

Software Mentioned

GEPIA

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