The roles of tumor-derived exosomes in non-small cell lung cancer and their clinical implications

Journal of Experimental & Clinical Cancer Research : CR
Hongmei ZhengSongqing Fan

Abstract

Non-small cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer cases, and it is one of the leading causes of cancer death in both men and women worldwide due to diagnosis in the advanced stage, rapid metastasis, and recurrence. At present, precision molecular targeted therapeutics directed toward NSCLC driven genes has made great progress and significantly improved the overall survival of patients with NSCLC, but can easily lead to acquired drug resistance. New methods are needed to develop real-time monitoring of drug efficacy and drug resistance, such as new molecular markers for more effective early detection and prediction of prognosis. Exosomes are nano-sized extracellular vesicles, containing proteins, nucleic acids and lipids, which are secreted by various cells, and they play an important role in the development of lung cancer by controlling a wide range of pathways. Tumor-derived exosomes are of great significance for guiding the targeted therapy of NSCLC and exosomes themselves can be a target for treatment. In this review, we describe the potential roles of tumor-derived exosomes and their clinical significance in NSCLC.

References

Mar 1, 1996·The Journal of Experimental Medicine·G RaposoH J Geuze
Oct 18, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·R Krishna, L D Mayer
Mar 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicolas BlanchardClaire Hivroz
Jun 12, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Sang-wook LeeKwang-Hyun Sohn
Mar 18, 2003·The Journal of Biological Chemistry·Ariel SavinaMaria I Colombo
Mar 31, 2004·Cellular and Molecular Life Sciences : CMLS·P M Jones, A M George
Feb 25, 2005·The New England Journal of Medicine·Susumu KobayashiBalázs Halmos
Mar 3, 2005·Journal of the National Cancer Institute·Hisayuki ShigematsuAdi F Gazdar
Feb 24, 2007·Nature Reviews. Cancer·Sreenath V SharmaDaniel A Haber
Jan 30, 2008·Current Protocols in Cell Biology·Clotilde ThéryAled Clayton
Jul 23, 2008·Journal of Translational Medicine·Thomas E IchimRichard H Tullis
Apr 16, 2009·Journal of Proteome Research·Javier Conde-VancellsJuan M Falcon-Perez
May 16, 2009·Current Opinion in Cell Biology·Mikael Simons, Graça Raposo
Dec 2, 2009·Methods in Molecular Biology·Chow H Lee
Dec 8, 2009·Nature Cell Biology·Matias OstrowskiClotilde Thery
Feb 3, 2011·Nature Communications·Leonora BalajJohan Skog
Mar 23, 2011·Nature Biotechnology·Lydia Alvarez-ErvitiMatthew J A Wood
Apr 6, 2011·Journal of Cellular Physiology·Valentina CiravoloSerenella M Pupa
Aug 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Thiha AungGerald G Wulf
Jan 12, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert C DoebeleD Ross Camidge
Apr 19, 2012·Nature Reviews. Molecular Cell Biology·Maria Mittelbrunn, Francisco Sánchez-Madrid
Apr 21, 2012·Journal of Proteomics·Patricia Bastos-AmadorJuan M Falcon-Perez
Jun 5, 2012·Nature Cell Biology·Maria Francesca BaiettiGuido David
Jun 23, 2012·Nature Reviews. Cancer·Gemma K Alderton
Jun 29, 2012·Journal of Translational Medicine·Annette M MarleauRichard H Tullis
Jul 4, 2012·Proceedings of the National Academy of Sciences of the United States of America·Muller FabbriCarlo M Croce
Sep 11, 2012·Biotechnology Advances·Ruenn Chai LaiSai Kiang Lim
Sep 25, 2012·BMC Cancer·Hamish W KingJonathan M Gleadle
Oct 4, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Shin-ichiro OhnoMasahiko Kuroda
Feb 13, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alice T Shaw, Jeffrey A Engelman
Feb 20, 2013·The Journal of Cell Biology·Clifford V HardingPhilip D Stahl
Feb 20, 2013·The Journal of Cell Biology·Graça Raposo, Willem Stoorvogel
Mar 30, 2013·Science·Bert VogelsteinKenneth W Kinzler
May 28, 2013·Cancer Metastasis Reviews·Asfar S AzmiFazlul H Sarkar
Jun 19, 2013·Biological Chemistry·Fatemeh Momen-HeraviWinston Patrick Kuo
Sep 7, 2013·Journal of Extracellular Vesicles·Chris GardinerIan L Sargent

❮ Previous
Next ❯

Citations

Feb 5, 2019·Cancer Metastasis Reviews·Mariantonia LogozziStefano Fais
Sep 7, 2019·PloS One·Xiang WangYuanliang Yan
May 29, 2020·Journal of Experimental & Clinical Cancer Research : CR·Marco RussanoDaniele Santini
Mar 28, 2019·Journal of Cellular and Molecular Medicine·Radivojka Bánová VulićĽudovít Škultéty
Jul 10, 2020·Respiratory Research·Aradhana MohanNavneet K Dhillon
Aug 4, 2020·World Journal of Stem Cells·Beatrice AraminiKhawaja Husnain Haider
Jul 30, 2019·BioMed Research International·Wenjuan TianBurong Li
Aug 17, 2019·International Journal of Molecular Sciences·Marzia Del ReRomano Danesi
Feb 6, 2020·Molecular Medicine Reports·Xiang WangZhijie Xu
Jun 4, 2020·Cancer Cell International·Leyla Norouzi-BaroughSadegh Shirian
Oct 30, 2019·International Journal of Oncology·Katherine L HarperAdrian Whitehouse
Dec 4, 2020·Emerging Topics in Life Sciences·Ainoa GuinartTeresa D Tetley
Dec 7, 2019·Toxicology and Applied Pharmacology·Yueming ChenLuyong Zhang
Mar 9, 2021·Frontiers in Cell and Developmental Biology·Xingping YangHongying Liao
Mar 14, 2021·Thorax·Anne TrappeJudith A Coppinger
Jun 28, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yuzhong ZhengMojtaba Falahati
Mar 26, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chen XueJunjun Jia
Apr 4, 2021·Cancers·Mateusz Smolarz, Piotr Widlak
Apr 30, 2021·Frontiers in Cell and Developmental Biology·Qi ChenXiaolan Zhu
May 4, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Federico CucchiaraMarzia Del Re
Jun 30, 2021·Clinical and Translational Medicine·Xiaoyun HeChunlin Ou
Aug 7, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Chunzhan WangHaitao Huang
Oct 2, 2021·Journal of Extracellular Vesicles·Julia DonzelliMeike J Saul
Nov 13, 2021·Pathology Oncology Research : POR·Hongmei ZhengSongqing Fan
Nov 26, 2021·Molecular Medicine Reports·Kwang Ho YooJaeyoung Kim
Jan 4, 2022·Journal of Biomedical Nanotechnology·Mengxi ZhuGaofeng Liang

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.